Camptothecin-20(S)-O-propionate
(Synonyms: Camptothecin-20-O-propionate) 目录号 : GC60669Camptothecin-20(S)-O-propionate(CZ48)是喜树碱(CPT)的类似物,是强效的抗肿瘤化合物。Camptothecin-20(S)-O-propionate(CZ48)是拓扑异构酶I(topoisomerase-Ι)的抑制剂。
Cas No.:194414-69-2
Sample solution is provided at 25 µL, 10mM.
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Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].
Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3].
[1]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [2]. Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. [3]. Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206.
Cas No. | 194414-69-2 | SDF | |
别名 | Camptothecin-20-O-propionate | ||
Canonical SMILES | O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O | ||
分子式 | C23H20N2O5 | 分子量 | 404.42 |
溶解度 | DMSO: 9.09 mg/mL (22.48 mM) | 储存条件 | Store at -20°C |
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1 mg | 5 mg | 10 mg | |
1 mM | 2.4727 mL | 12.3634 mL | 24.7268 mL |
5 mM | 0.4945 mL | 2.4727 mL | 4.9454 mL |
10 mM | 0.2473 mL | 1.2363 mL | 2.4727 mL |
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2.
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Crystalline Camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts
Cancer Res 2009 Jun 1;69(11):4742-9.PMID:19458069DOI:10.1158/0008-5472.CAN-08-4452
To find a more effective and less toxic chemotherapeutic agent, we have successfully prepared crystalline Camptothecin-20(S)-O-propionate hydrate (CZ48) by reacting camptothecin with propionic anhydride using concentrated sulfuric acid as catalyst. The biological effectiveness of this new anticancer agent was evaluated by using xenografts of human cancers in nude mice as the testing models. The extensive treatment of 21 human tumors with various dose levels of CZ48 has shown that this agent is highly effective against many different human tumors tested with a striking lack of toxicity. Of the 21 human tumor lines tested, 9 regressed, 5 were <10% of the control, 3 were <20%, and 2 were <40%. Two tumors did not respond. The total response rate was 90% (19 of 21). No toxicity was observed in mice. The effective doses required to achieve the positive response varied from 100 to 1,000 mg/kg/d depending on the tumors. The maximum tolerated dose was not reached because of the nontoxic nature of the drug in mice. Thus, this compound has a much wider therapeutic index compared with that of the existing anticancer drugs currently in use.