|4-hydroxy Nonenal 目录号 GC42410|
Sample solution is provided at 25 µL, 10mM.
|Cas No.||75899-68-2||SDF||Download SDF|
|溶解度||50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL Ethanol||储存条件||Store at -80°C|
|General tips||For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.|
|Shipping Condition||Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid., 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation. It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.,, 4-hydroxy Nonenal inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.
. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).