4-hydroxy Nonenal
(Synonyms: 4-羟基壬烯醛,4-HNE) 目录号 : GC42410A lipid peroxidation product
Cas No.:75899-68-2
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
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- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.[1],[2] 4-hydroxy Nonenal is widely used as a marker of lipid peroxidation.[2] It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.[1],[2],[3] 4-hydroxy Nonenal inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.[2]
4-羟基壬烯醛是一种脂质过氧化产物,来源于氧化的ω-6多不饱和脂肪酸,如花生四烯酸。[1] ,[2]4-羟基壬烯醛被广泛用作脂质过氧化的标志物。[2] 它具有多种生物活性,如细胞毒性、生长抑制活性、遗传毒性和趋化活性。[1] ,[2],[3]4-羟基壬烯醛在10-50µM时抑制促氧化剂诱导的线粒体Ca2+释放。[2]
Reference:
[1]. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
[2]. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
[3]. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).
Cas No. | 75899-68-2 | SDF | |
别名 | 4-羟基壬烯醛,4-HNE | ||
化学名 | (±)-4-hydroxy-2E-nonenal | ||
Canonical SMILES | CCCCCC(O)\C=C\C=O | ||
分子式 | C9H16O2 | 分子量 | 156.2 |
溶解度 | 50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL Ethanol | 储存条件 | -20°C, protect from light. |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 6.402 mL | 32.0102 mL | 64.0205 mL |
5 mM | 1.2804 mL | 6.402 mL | 12.8041 mL |
10 mM | 0.6402 mL | 3.201 mL | 6.402 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。