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11β-Prostaglandin F2α-d4 Sale

(Synonyms: 9α,11βPGF2αd4, 11βPGF2αd4, 11epi PGF2αd4) 目录号 : GC46412

An internal standard for the quantification of 11β-PGF F

11β-Prostaglandin F2α-d4 Chemical Structure

Cas No.:1240398-18-8

规格 价格 库存 购买数量
50 μg
¥1,165.00
现货
100 μg
¥2,209.00
现货
500 μg
¥5,243.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

11β-Prostaglandin F-d4 (11β-PGF-d4) is intended for use as an internal standard for the quantification of 11β-PGF by GC- or LC-MS. 11β-PGF is the primary metabolite of PGD2 .1 It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase in the liver or lung.2 11β-PGF induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF (FP) receptors, with an EC50 value of 0.045 µM.1 It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.3 11β-PGF (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.4

1.Giles, H., Bolofo, M.L., Lydford, S.J., et al.A comparative study of the prostanoid receptor profile of 9α 11 β-prostaglandin F2 and prostaglandin D2Br. J. Pharmacol.104(2)541-549(1991) 2.Watanabe, K.Prostaglandin F synthaseProstaglandins Other Lipid Mediat.68-69401-407(2002) 3.Coleman, R.A., and Sheldrick, R.L.G.Prostanoid-induced contraction of human bronchial smooth muscle is mediated by TP-receptorsBr. J. Pharmacol.96(3)688-692(1989) 4.Yoda, T., Kikuchi, K., Miki, Y., et al.11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates prostaglandin F receptor and induces slug expression in breast cancerMol. Cell. Endocrinol.413236-247(2015)

Chemical Properties

Cas No. 1240398-18-8 SDF
别名 9α,11βPGF2αd4, 11βPGF2αd4, 11epi PGF2αd4
Canonical SMILES O[C@@H]1[C@H](/C=C/[C@H](O)CCCCC)[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])CC(O)=O)[C@@H](O)C1
分子式 C20H30D4O5 分子量 358.5
溶解度 Ethanol: 100 mg/ml,DMF: 100 mg/ml,DMSO: 100 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 2.7894 mL 13.947 mL 27.894 mL
5 mM 0.5579 mL 2.7894 mL 5.5788 mL
10 mM 0.2789 mL 1.3947 mL 2.7894 mL
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