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UNG E.Coli

目录号 : GP22388

Uracil DNA Glycosylase E.Coli Recombinant

UNG E.Coli Chemical Structure

规格 价格 库存 购买数量
2μg
¥840.00
5-10工作日
10μg
¥2,030.00
5-10工作日
1mg
¥72,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

UNG E.Coli Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a) and having a molecular mass of 28.1kDa.

Product Data

Purity Greater than 90.0% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered clear solution. Shipping Condition Shipped with Ice Packs.
Synonyms UDG; b2580; JW2564; EC 3.2.2.27; DGU; UNG15; HIGM5; Uracil-DNA Glycosylase 1; EC 3.2.2; HIGM4; UNG2.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MGSMANELTW HDVLAEEKQQ PYFLNTLQTV ASERQSGVTI YPPQKDVFNAFRFTELGDVK VVILGQDPYH GPGQAHGLAF SVRPGIAIPP SLLNMYKELE NTIPGFTRPN HGYLESWARQGVLLLNTVLT VRAGQAHSHA SLGWETFTDK VISLINQHRE GVVFLLWGSH AQKKGAIIDK QRHHVLKAPH PSPLSAHRGF FGCNHFVLANQWLEQRGETP IDWMPVLPAE SE
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Formulation UNG protein solution (0.5mg/ml) containing 20mM Tris-HClbuffer (pH8.0) and 10% glycerol.

Introduction

UNG is a member of the Uracil-DNA glycosylase family. One of his functions is to preventmutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond andinitiating the base-excision repair (BER) pathway. Uracil bases are formed as a result of cytosinedeamination or misincorporation of dUMP residues. After a mutation is formed,the mutagenic threatof uracil propagates through any subsequent DNA replication steps. Among the diseases associated with UNG are: congenital rubella,and immunodeficiency with hyper igm type 4.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.