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Tyrphostin 9 Sale

(Synonyms: 酪氨酸磷酸化抑制剂A9,Tyrphostin 9; Malonoben) 目录号 : GC10758

An inhibitor of EGF receptor kinase

Tyrphostin 9 Chemical Structure

Cas No.:10537-47-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
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25mg
¥378.00
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50mg
¥441.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM [1].

Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].

In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].

References:
[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
[2] Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.

Chemical Properties

Cas No. 10537-47-0 SDF
别名 酪氨酸磷酸化抑制剂A9,Tyrphostin 9; Malonoben
化学名 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile
Canonical SMILES CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N
分子式 C18H22N2O 分子量 282.38
溶解度 ≥ 14.1mg/mL in DMSO 储存条件 Store at -20°C
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1 mM 3.5413 mL 17.7066 mL 35.4133 mL
5 mM 0.7083 mL 3.5413 mL 7.0827 mL
10 mM 0.3541 mL 1.7707 mL 3.5413 mL
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