Sultamicillin tosylate
(Synonyms: 舒巴西林) 目录号 : GC39544
Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
Cas No.:83105-70-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
| Cas No. | 83105-70-8 | SDF | |
| 别名 | 舒巴西林 | ||
| Canonical SMILES | O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](N)C3=CC=CC=C3)=O)N1C2=O)OCOC([C@@H](C(C)(C)S(C4C5)(=O)=O)N4C5=O)=O.O=S(C6=CC=C(C)C=C6)(O)=O | ||
| 分子式 | C32H38N4O12S3 | 分子量 | 766.86 |
| 溶解度 | DMSO: 125 mg/mL (163.00 mM) | 储存条件 | 4°C, protect from light |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.304 mL | 6.5201 mL | 13.0402 mL |
| 5 mM | 0.2608 mL | 1.304 mL | 2.608 mL |
| 10 mM | 0.1304 mL | 0.652 mL | 1.304 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Ternary system of Sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine: susceptibility against methicillin-resistant Staphylococcus aureus
Ther Deliv 2022 Dec;13(12):561-575.PMID:36861310DOI:10.4155/tde-2022-0050.
Aim: This study investigated the effect of complex formation between Sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections.