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Stercobilin (hydrochloride) Sale

(Synonyms: (–)-Stercobilin, L-Stercobilin) 目录号 : GC49844

A fecal pigment and metabolite of bilirubin

Stercobilin (hydrochloride) Chemical Structure

Cas No.:5370-34-3

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1 mg
¥1,078.00
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5 mg
¥4,045.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Stercobilin is a fecal pigment and a metabolite of the heme catabolite bilirubin .1 It induces DNA damage in a comet assay in HepG2 cells when used at concentrations ranging from 0.5 to 17 µM.2 Stercobilin (20 and 30 µM) induces activation of NF-κB in a reporter assay and increases the expression of the genes encoding TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS), and COX-2 in RAW 264.7 macrophages.3 Fecal and plasma levels of stercobilin are increased in ob/ob mice.

1.VÍtek, L., Majer, F., MuchovÁ, L., et al.Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal floraJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.833(2)149-157(2006) 2.MÖlzer, C., Pfleger, B., Putz, E., et al.In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cellsExp. Cell Res.319(4)536-545(2013) 3.Sanada, S., Suzuki, T., Nagata, A., et al.Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob miceSci. Rep.10(1)6479(2020)

Chemical Properties

Cas No. 5370-34-3 SDF Download SDF
别名 (–)-Stercobilin, L-Stercobilin
Canonical SMILES OC(CCC1=C(C)C(C[C@@H]2NC([C@H](CC)[C@H]2C)=O)=N/C1=C\C3=C(CCC(O)=O)C(C)=C(C[C@@H]4NC([C@H](C)[C@H]4CC)=O)N3)=O.Cl
分子式 C33H46N4O6 • XHCl 分子量 594.8
溶解度 DMF: soluble,NaOH (aq): soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.6812 mL 8.4062 mL 16.8124 mL
5 mM 0.3362 mL 1.6812 mL 3.3625 mL
10 mM 0.1681 mL 0.8406 mL 1.6812 mL
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