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SL-164 Sale

目录号 : GC48080

An Analytical Reference Standard

SL-164 Chemical Structure

Cas No.:3476-88-8

规格 价格 库存 购买数量
1 mg
¥1,113.00
现货
5 mg
¥5,019.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

SL-164 is an analytical reference standard categorized as a quinazolinone. SL-164 has sedative properties.1 This product is intended for research and forensic applications.

1.Saito, C., Sakai, S., Yukawa, Y., et al.Pharmacological studies on 2-methyl-3(2'-methyl-4'-chlorophenyl)-5-chloro-4[H)-quinazolinone (SL-164)Arzneimittelforschung19(12)1945-1949(1969)

Chemical Properties

Cas No. 3476-88-8 SDF
Canonical SMILES ClC1=C(C(N(C2=CC=C(Cl)C=C2C)C(C)=N3)=O)C3=CC=C1
分子式 C16H12Cl2N2O 分子量 319.2
溶解度 DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml,DMSO: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1328 mL 15.6642 mL 31.3283 mL
5 mM 0.6266 mL 3.1328 mL 6.2657 mL
10 mM 0.3133 mL 1.5664 mL 3.1328 mL
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Research Update

Return of the Quaaludes? Prolonged agitated delirium after intentional ingestion of the methaqualone analog SL-164 - a case report

Subst Abus 2021;42(4):503-505.PMID:33760714DOI:10.1080/08897077.2021.1903648.

Background: A 22-year-old male with a known history of drug abuse presented to our department with prolonged agitated delirium, myocloni, tachycardia and subfebrile temperature after the deliberate ingestion of opium poppy tea (Papaver somniferum L.) together with the methaqualone analog SL-164 (5-chloro-3-(4-chloro-2-methylphenyl)-2-methyl-4(3H)-quinazolinone) which is sold online as a designer drug. Methods: SL-164 and its hydroxy metabolites were detected in serum and urine via liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-QTOF-MS). Results: The pronounced delirium was treated with benzodiazepines and neuroleptics; temporary medical restraint had to be applied. Symptoms completely resolved over the next 72 h and the patient was discharged on day three able to give consent. Conclusions: Although methaqualone was a popular and widespread sedative in the 1950s and 60 s before its discontinuation in the USA in 1985, derivatives of the methaqualone class have not previously played a large role as drugs of abuse in the rapidly growing market of new psychoactive substances. To our knowledge, this is the first case of agitated delirium with detection of SL-164 and hydroxylated metabolites in a patient's serum and urine.

Qua-Alluding to the Past: A Case of Methaqualone Analog Ingestion

J Anal Toxicol 2021 Sep 21;bkab103.PMID:34545408DOI:10.1093/jat/bkab103.

Methaqualone, known previously under the brand name Quaalude, is a Schedule I sedative hypnotic drug that may cause neurotoxicity in overdose, characterized by somnolence, hyperreflexia and muscular hyperactivity. We present a case of a 21-year-old male who reportedly ingested methaqualone in addition to insufflation of street cocaine. He subsequently developed hypoxia, hyperreflexia, myoclonus, and altered mental status. His laboratory results were notable for the presence of methemoglobinemia, which was most likely due to a cocaine contaminant. Laboratory analysis of the alleged methaqualone pills identified the substance as SL-164, a dichlorinated methaqualone analog. Urine toxicology results were positive for SL-164 (and presumed metabolites) as well as for cocaine and tetrahydrocannabinol metabolites. The patient was treated with supplemental oxygen and a benzodiazepine (lorazepam) and observed in the Emergency Department (ED) until his symptoms resolved. This case highlights current community access to methaqualone analogs. The case also focuses on laboratory techniques used to identify the methaqualone analog.