Rimsulfuron
(Synonyms: 砜嘧磺隆,DPX-E9636) 目录号 : GC63324
Rimsulfuron (DPX-E9636) 是一种磺酰脲类除草剂，在玉米出苗后用于控制禾草和一些阔叶杂草。
Cas No.:122931-48-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >96.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds[1][2].
Rimsulfuron (DPX-E9636) was also metabolized in vitro by maize microsomes in a NADPH-dependent reaction to the same hydroxylated product, suggesting involvement of cytochrome P450[1].
[1]. M.K.Koeppe, et al. Basis of Selectivity of the Herbicide Rimsulfuron in Maize.
| Cas No. | 122931-48-0 | SDF | |
| 别名 | 砜嘧磺隆,DPX-E9636 | ||
| 分子式 | C14H17N5O7S2 | 分子量 | 431.44 |
| 溶解度 | DMSO : 33.33 mg/mL (77.25 mM; ultrasonic and warming and heat to 60°C) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.3178 mL | 11.5891 mL | 23.1782 mL |
| 5 mM | 0.4636 mL | 2.3178 mL | 4.6356 mL |
| 10 mM | 0.2318 mL | 1.1589 mL | 2.3178 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Peer review of the pesticide risk assessment of the active substance Rimsulfuron
EFSA J 2022 Sep 29;20(9):e07447.PMID:36204157DOI:10.2903/j.efsa.2022.7447.
The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Slovenia, and co-rapporteur Member State, Finland, for the pesticide active substance Rimsulfuron are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Rimsulfuron as an herbicide on maize, potato and tomato and updated following the request to update the risk assessment of Rimsulfuron in view of the renewal process under Commission Implementing Regulation (EU) No 844/2012. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are reported where identified.
Peer review of the pesticide risk assessment of the active substance Rimsulfuron
EFSA J 2018 May 28;16(5):e05258.PMID:32625897DOI:10.2903/j.efsa.2018.5258.
The conclusions of EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Slovenia, and co-rapporteur Member State, Finland, for the pesticide active substance Rimsulfuron are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of Rimsulfuron as an herbicide on maize, potato and tomato. The reliable end points, appropriate for use in regulatory risk assessment, are presented. Missing information identified as being required by the regulatory framework is listed. Concerns are identified.
Simultaneous Determination of Rimsulfuron and Haloxyfop-P-methyl and Its Metabolite Haloxyfop in Tobacco Leaf by LC-MS/MS
J AOAC Int 2019 Sep 1;102(5):1632-1640.PMID:30674371DOI:10.5740/jaoacint.18-0280.
Background: Tobacco (Nicotiana tabacum L.), is an important economic crop. In China, the use of Rimsulfuron and haloxyfop-P-methyl herbicides for weed management during the planting period is necessary to improve the production of tobacco. Objective: To establish and validate a quick, easy, cheap, effective, rugged, and safe LC-MS/MS method to determine Rimsulfuron, haloxyfop-P-methyl, and haloxyfop in tobacco leaf samples. Methods: We optimized MS/MS conditions and chromatographic conditions for optimal detection conditions. The extraction solvent and sorbent were optimized, and the analysis of variance was applied to analyze the pretreatment method to obtain the optimal pretreatment conditions. Results: The validation results showed that the proposed method exhibited good linearity (R² > 0.9978), satisfactory recovery (72.51-101.60%) and low LOQ (0.02-1.00 mg/kg). The matrix effects of the three analytes in the two tobacco leaf matrixes were different. The dissipation results showed that the half-lives of Rimsulfuron and haloxyfop-P-methyl in fresh tobacco leaf samples were ranged from 2.4 to 3.7 days. The final residues of Rimsulfuron, haloxyfop-P-methyl, and haloxyfop in flue-cured tobacco leaf samples were all lower than the LOQ. Conclusions: The results demonstrate that the developed method could be used to detect Rimsulfuron, haloxyfop-P-methyl, and haloxyfop in tobacco leaf matrixes. Highlights: A method for simultaneous determination of Rimsulfuron, haloxyfop-P-methyl, and haloxyfop in tobacco leaf samples with high sensitivity has been established for the first time.
Residue Behavior and Risk Assessment of Rimsulfuron and Quizalofop-P-ethyl in Potato Under Field Conditions
Bull Environ Contam Toxicol 2020 Oct;105(4):602-606.PMID:32978647DOI:10.1007/s00128-020-03002-9.
A method for simultaneous quantitation of Rimsulfuron, quizalofop-P-ethyl and quizalofop-P in potato plant, soil and potato tuber samples was established. The mean recoveries of Rimsulfuron, quizalofop-P-ethyl and quizalofop-P in different matrices spiked with them were 81.4%-101.1%, 76.1%-99.0% and 77.4%-106.4% with relative standard deviations (RSDs) of 2.7%-13.3%, 0.9%-5.5%, 1.7%-11.3%, respectively. The open-field trials in China were conducted in potato cultivation system of Changchun and Jinan. The results indicated that the half-lives of Rimsulfuron and quizalofop-P-ethyl were 0.04-13.1 days. The residues of quizalofop-P during the harvest time in Jinan soil were < 0.01-0.044 mg kg-1, while there was no residue of target herbicides detected in all other samples. The risk assessment results demonstrated that the risk quotients (RQs) of Rimsulfuron and quizalofop-P-ethyl were 7.857 × 10-5 and 8.730 × 10-3, respectively, which exhibited an acceptable dietary risk to Chinese consumers.
Metabolism of quizalofop and Rimsulfuron in herbicide resistant grain sorghum
Pestic Biochem Physiol 2013 Jan;105(1):24-7.PMID:24238286DOI:10.1016/j.pestbp.2012.11.003.
Studies were conducted to determine if herbicide metabolism is an additional mechanism that could explain the resistance of ACCase- and ALS-resistant grain sorghum to quizalofop and Rimsulfuron, respectively. ACCase- and ALS-resistant and -susceptible genetic lines were grown under controlled conditions and treated at the 4-leaf stage with (14)C-labeled quizalofop and Rimsulfuron. Plants were harvested at 3, 5, and 7d after treatments. In the ACCase metabolism experiment, resistant grain sorghum transformed 88% of quizalofop-ethyl to quizalofop while 91% of the inactive was converted to active form by the susceptible plants 3DAT. By 7DAT, all inactive quizalofop-ethyl was converted to active quizalofop. In the ALS metabolism study, two distinct metabolites were produced from Rimsulfuron. Metabolism rate was similar between resistant lines (TX430R and N223R) in all harvest dates except at 7 DAT; however, more rapid metabolism were observed when resistant were compared with the susceptible genotypes (TX430S and N223S). The percentage of recovered Rimsulfuron 3DAT corresponded to 80% and 83% in the resistant compared to 87% in the susceptible grain sorghum. At 5DAT, metabolism was near steady in all sorghum plants but by 7DAT, resistant genotypes metabolized 4-12% more than the susceptible sorghum. Metabolism of Rimsulfuron in ALS-resistant grain sorghum is an added mechanism that could help elevate the level of Rimsulfuron resistance.