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Home >> Signaling Pathways >> Tyrosine Kinase >> FLT3

FLT3(FMS样酪氨酸激酶3)

FLT3 (FMS-like tyrosine kinase 3) is a cytokine receptor which belongs to the receptor tyrosine kinase class III and plays a role in cell survival, proliferation, and differentiation.

Products for  FLT3

  1. Cat.No. 产品名称 Information
  2. GC32769 MRX-2843 (UNC2371)

    UNC2371

     A Mer and FLT3 inhibitor
  3. GC19772 FLT3-IN-3

    SAN50900

     An FLT3 inhibitor
  4. GC19482 Gilteritinib

    吉列替尼,ASP2215

     Gilteritinib（ASP2215，Xospata）用于复发和/或难治性 AML (R/R AML)。
  5. GC19332 Sitravatinib

    MGCD516; MG-516

     A multi-kinase inhibitor
  6. GC19158 FLT3-IN-2 An inhibitor of FLT3, c-Kit, and c-FMS
  7. GC19092 CCT241736 A dual inhibitor of Aurora kinases and FLT3
  8. GC19080 BPR1J-097 An FLT3 inhibitor
  9. GC18167 AC710

    N-[4-[[[[5-(叔丁基)-3-异恶唑基]氨基]羰基]氨基]苯基]-5-[(1-乙基-2,2,6,6-四甲基-4-哌啶基)氧基]-2-吡啶甲酰胺

     A PDGFR family kinase inhibitor
  10. GC12251 Tandutinib (MLN518) HCl FLT3 inhibitor,potent and selective
  11. GC14582 SU5614

    (3Z)-5-氯-3-[(3,5-二甲基-1H-吡咯-2-基)亚甲基]-1,3-二氢-2H-吲哚-2-酮

     A multi-kinase inhibitor
  12. GC17959 AZD2932 A multi-kinase inhibitor
  13. GC16604 Altiratinib

    DCC-2701

     A multiple kinase inhibitor
  14. GC15556 UNC2025

    反式-4-[2-(丁基氨基)-5-[4-[(4-甲基-1-哌嗪基)甲基]苯基]-7H-吡咯并[2,3-D]嘧啶-7-基]-环己醇

     An orally bioavailable inhibitor of Mer and Flt3
  15. GC12178 G-749

    G-749

     An FLT3 kinase inhibitor
  16. GC11205 5'-Fluoroindirubinoxime

    5'-FIO

     An inhibitor of FLT3 kinase
  17. GC14007 DCC-2036 (Rebastinib)

    N-[3-叔丁基-1-(喹啉-6-基)-1H-吡唑-5-基]-N'-[2-氟-4-[(2-(甲基氨基甲酰基)吡啶-4-基)氧]苯基]脲,DCC-2036

     An orally bioavailable tyrosine kinase inhibitor
  18. GC15254 Tandutinib (MLN518)

    坦度替尼; MLN518; CT53518

     An antagonist of PDGFRβ, FLT3, and c-Kit
  19. GC14974 AMG 925 A dual inhibitor of FLT3 and Cdk4
  20. GC15739 CHIR-124

    4-[((3S)-1-氮杂双环[2,2,2]辛-3-基)氨基]-3-(1H-苯并咪唑-2-基)-6-氯喹啉-2(1H)-酮

     A selective Chk1 inhibitor
  21. GC14906 Crenolanib (CP-868596)

    [1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺,CP-868596;CP 868596;CP868596

     An inhibitor of PDGFRα/β and FLT3
  22. GC12058 TCS 359

    Fms-like Tyrosine Kinase Inhibitor, TCS 359

     A cell-permeable FLT3 inhibitor
  23. GC17615 Quizartinib (AC220)

    奎扎替尼; AC220

     Quizartinib (AC220)是一种高效的第二代Fms样酪氨酸激酶3（FLT3）抑制剂，对FLT3-ITD和FLT3-WT的IC50值分别为1.1nM和4.2nM。
  24. GC14396 Ponatinib (AP24534)

    普纳替尼; AP24534

     An inhibitor of native and mutant Bcr-Abl
  25. GC15779 Cabozantinib (XL184, BMS-907351)

    卡博替尼; XL184; BMS-907351

     Cabozantinib (XL184,BMS-907351) 是一种新型 MET 和 VEGFR2 抑制剂，可同时抑制转移、血管生成和肿瘤生长。
  26. GC13547 Dovitinib (TKI-258, CHIR-258)

    多韦替尼; CHIR-258; TKI258

     Dovitinib (TKI-258, CHIR-258)是一种高效，具有口服活性和安全药代动力学特性的小分子多激酶抑制剂，作用于FLT3、KIT和FGFR等靶点，IC50值分别为1、2和8-9nM。
  27. GC17958 Linifanib (ABT-869)

    利尼伐尼,ABT-869; AL-39324

     A dual VEGFR and PDGFR family kinase inhibitor
  28. GC16499 Sorafenib Tosylate

    甲苯磺酸索拉非尼; Bay 43-9006 Tosylate

     A multi-kinase inhibitor
  29. GC17033 Lestaurtinib

    来他替尼; CEP-701; KT-5555

     A potent JAK2 and PRK1 kinase inhibitor
  30. GC15307 SU5416

    司马沙尼; SU5416; Semaxanib

    SU5416 是一种有效的小分子血管内皮生长因子受体 (VEGFR) 抑制剂。
  31. GC11455 Silvestrol

    (1R,2R,3S,3AR,8BS)-6-[[(2S,3R,6R)-6-[(1R)-1,2-二羟基乙基]-3-甲氧基-1,4-二氧己环-2-基]氧基]-2,3,3A,8B-四氢-1,8B-二羟基-8-甲氧基-3A-(4-甲氧基苯基)-3-苯基-1H-环戊烯并[B]苯并呋喃-2-羧酸甲酯,(-)-Silvestrol

     Silvestrol 是一种真核翻译起始因子 4A (eIF4A) 抑制剂，从 Agave americana Linn 中分离出来。Silvestrol 诱导自噬和半胱天冬酶介导的细胞凋亡。
  32. GC12064 SB1317

    14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯,TG02;SB 1317;TG 02;SB-1317;TG-02

     A multi-kinase inhibitor
  33. GC11057 LY2801653

    梅沙替尼,LY-2801653;LY 2801653

     A MET kinase inhibitor
  34. GC10914 AST 487

    NVP-AST 487

     A multi-kinase inhibitor
  35. GC16391 Amuvatinib (MP-470, HPK 56)

    N-(1,3-苯并二氧戊环-5-基甲基)-4-苯并呋喃并[3,2-D]嘧啶-4-基-1-哌嗪硫代甲酰胺,MP470,MP 470,HPK56

     A multi-targeted RTK inhibitor
  36. GC14592 KW 2449

    [4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮

     A multi-kinase inhibitor
  37. GC10638 AT9283 A broad spectrum kinase inhibitor
  38. GC16519 ENMD-2076

    6-(4-甲基-1-哌嗪基)-N-(5-甲基-1H-吡唑-3-基)-2-[(1E)-2-苯乙烯基]-4-嘧啶胺

     A multi-kinase inhibitor
  39. GC12145 ENMD-2076 L-(+)-Tartaric acid ENMD-2076 L-(+)-Tartaric acid 是一种多靶点激酶抑制剂，对 Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1 的 IC50 为 1.86、14、58.2、15.9、92.7、70.8、56.4 nM , FGFR2, Src, PDGFRα, 分别。
  40. GC13848 LY2784544

    Gandotinib

     Potent inhibitor of JAK2
  41. GC10035 TG101209

    N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺,TG-101209

     An inhibitor of JAK2, FLT3, RET, and JAK3
  42. GC17369 Sorafenib

    索拉非尼; Bay 43-9006

     索拉非尼Sorafenib是Raf-1和B-Raf的多激酶抑制剂，IC50分别为6 nM和22 nM;Sorafenib对VEGFR-2 VEGFR-3 PDGFR-β Flt-3和c-KIT也有抑制作用，IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM;索拉非尼能诱导自噬细胞凋亡和激活铁死亡，并具有抗肿瘤活性。

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