Neurokinin Receptor(神经激肽受体)
There are three main classes of neurokinin receptors: NK1R (the substance P preferring receptor), NK2R, and NK3R. These tachykinin receptors belong to the class I (rhodopsin-like) G-protein coupled receptor (GPCR) family. The various tachykinins have different binding affinities to the neurokinin receptors: NK1R, NK2R, and NK3R. These neurokinin receptors are in the superfamily of transmembrane G-protein coupled receptors (GPCR) and contain seven transmembrane loops. Neurokinin-1 receptor interacts with the Gαq-protein and induces activation of phospholipase C followed by production of inositol triphosphate (IP3) leading to elevation of intracellular calcium as a second messenger. Further, cyclic AMP (cAMP) is stimulated by NK1R coupled to the Gαs-protein. The neurokinin receptors are expressed on many cell types and tissues.
Products for Neurokinin Receptor
- Cat.No. 产品名称 Information
- GC30104 Fezolinetant (ESN-364) Fezolinetant (ESN-364) 是一种神经激肽 3 受体 (NK3R) 的拮抗剂,用于治疗更年期潮热。
- GC17596 Netupitant An NK1 receptor antagonist
- GC15449 Rolapitant A potent NK1 receptor antagonist
- GC16408 GR 159897 A nonpeptide NK2 receptor antagonist
- GC18128 L-732,138 An NK1 receptor antagonist
- GC18080 GR 73632 GR 73632 是一种新型速激肽神经激肽 1 (NK-1) 受体激动剂。
- GC13239 Hemokinin 1 (mouse) Hemokinin 1 (mouse) 是一种选择性的神经激肽-1 受体激动剂,对人 NK1 受体和人 NK2 受体的 Ki 分别为 0.175 nM 和 560 nM。
- GC15122 [bAla8]-Neurokinin A(4-10) [bAla8]-Neurokinin A(4-10) 是一种神经激肽 2 (NK2) 受体激动剂。
- GC17547 MEN 10376 An NK2 receptor antagonist
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GC11801
Neurokinin B (human, porcine)
Neurokinin B (human, porcine) 属于肽的速激肽家族。
- GC13610 [Sar9,Met(O2)11]-Substance P A peptide NK1 receptor agonist
- GC15649 Substance P An endogenous NK1 receptor agonist
- GC11738 Neurokinin A (porcine) 神经激肽 A(猪)(物质 K)是速激肽家族的一种肽神经递质,通过 NK-2 受体起作用。
- GC14839 Senktide A potent NK3 receptor agonist
- GC15591 Eprazinone 2HCl An antitussive agent
- GC10659 Fosaprepitant dimeglumine salt A prodrug form of aprepitant
- GC16246 Fosaprepitant A prodrug form of aprepitant
- GC15200 Aprepitant An antiemetic and NK1 antagonist
- GC16026 Talnetant A nonpeptide NK3 antagonist
- GC10107 SB-222200 An NK3 receptor antagonist