Apoptosis Inducers(细胞凋亡诱导剂)
Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.
Products for Apoptosis Inducers
- Cat.No. 产品名称 Information
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GC16037
7BIO
7-Bromoindirubin-3’-oxime
A caspase-independent (nonapoptotic) cell death inducer - GC14791 F16 A potential antitumor agent
- GC13034 ML-291 An activator of apoptosis through UPR
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GC14847
Psoralidin
补骨脂定
A furanocoumarin with anti-cancer activity -
GC16375
(±)-Jasmonic Acid methyl ester
甲基茉莉酮酸酯,(±)-Methyl Jasmonate
A plant growth regulator -
GC11988
15-acetoxy Scirpenol
15-乙酰蛇形菌素
A trichothecene mycotoxin -
GC10661
Destruxin B
黑僵菌素 B
An insecticidal mycotoxin -
GC16661
Citrinin
桔霉素; NSC 186
Citrinin是一种具有多种生物活性的霉菌毒素,由青霉属、曲霉属和红曲霉属的几种真菌菌株产生。 -
GC14050
MPI-0441138
EP128265
A potent inducer of apoptosis and growth inhibition -
GC11834
Epibrassinolide
表油菜素内酯; 24-Epibrassinolide; B1105; BP55
A brassinosteroid with protective effects -
GC15036
Raltegravir potassium salt
雷特格韦钾盐; MK 0518 potassium
An HIV-1 integrase inhibitor - GC11710 CFM 4 CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合,导致 G2M 细胞周期停滞,并诱导细胞凋亡,IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
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GC15035
PM00104
Potent antimyeloma agent
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GC14312
Meisoindigo
甲异靛; Dian III; N-Methylisoindigotin; Natura-α
An anticancer agent -
GC10744
Bendamustine HCl
盐酸苯达莫司汀; SDX-105
A DNA alkylating agent -
GC17198
Cycloheximide
Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
环己酰亚胺是一种抗生素,它在翻译水平上抑制蛋白质合成,仅对真核细胞的细胞质(80s)核糖体起作用。 -
GC15503
NSC 687852 (b-AP15)
b-AP15
An inhibitor of the deubiquitinases USP14 and UCHL5 -
GC12353
Mitomycin C
丝裂霉素 C,Ametycine
Mitomycin C是一种抗生素,从链霉菌(Streptomyces Caespitosus)或淡紫色链霉菌(Streptomyces Lavendulae)中分离出来。 -
GC17131
Streptozocin
链脲佐菌素; Streptozotocin; U 9889
Streptozocin 是一种有效的 DNA 甲基化抗生素,是一种天然存在的亚硝基酰胺,在实验模型中广泛用于产生糖尿病。 -
GC10315
Plumbagin
白花丹素; 2-Methyljuglone
A natural naphthoquinone -
GC10282
Piperlongumine
荜茇酰胺; Piplartine
An alkaloid with anticancer and antioxidant activities -
GC14860
Oncrasin 1
1-(4-氯苄基)-1H-吲哚-3-甲醛
An anticancer agent -
GC15484
Deguelin
鱼藤素; (-)-Deguelin; (-)-cis-Deguelin
A potent antiproliferative rotenoid compound -
GC17969
CHM 1
NSC656158
An inhibitor of tubulin polymerization -
GC16866
Actinomycin D
放线菌素D,DACTINOMYCIN
阿克替诺霉素D(也称为达克替诺霉素)是一种从链霉菌属中分离出来的天然色胺肽,含有一个杂环色团和两个五元环戊肽内酯环。 - GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物,对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
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GC18044
Trabectedin
曲贝替定; Ecteinascidin 743; ET-743
An alkaloid with anticancer activity -
GC16055
SMIP004
N-(4-丁基-2-甲基苯基)乙酰胺,SMIP 004;SMIP-004
SMIP004 是一种 SKP2 E3 连接酶抑制剂,可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。 -
GC12857
R1530
5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓,R 1530;R-1530
A multi-kinase inhibitor -
GC17874
Matrine
苦参碱; Matridin-15-one; Vegard; α-Matrine
苦参碱(Matrine)是一种存在于槐属植物中的生物碱,可作为 kappa 阿片受体和µ-受体激动剂。 -
GC12139
Gambogic Acid
藤黄酸; Beta-Guttiferrin
Gambogic Acid 是一种细胞渗透性 caspase 激活剂和细胞凋亡诱导剂,常用于乳腺癌、肺癌和肝癌等的研究。 -
GC14787
Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow
A yellow pigment with diverse biological activities -
GC16116
Costunolide
木香烃内酯; (+)-Costunolide; Costus lactone
A natural sesquiterpene lactone -
GC14065
Capsaicin
辣椒素; (E)-Capsaicin
辣椒素是一种高度选择性的瞬时受体电位阳离子通道激动剂,亚家族 V,成员 1 (TRPV1),一种配体门控的非选择性阳离子通道,优先在小直径感觉神经元上表达 < /sup>。 -
GC11632
Brassinolide
油菜素内酯; Brassin lactone
A plant growth regulator -
GC10480
Betulinic acid
白桦脂酸; Lupatic acid; Betulic acid
白桦脂酸(Betulinic acid)是一种天然的五环三萜类化合物,是真核细胞拓扑异构酶I的抑制剂,IC50值为5μM。 -
GC12053
BAM7
BAM 7;BAM-7
A direct activator of Bax -
GC12791
3,3'-Diindolylmethane
3,3'-二吲哚甲烷,diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236
A phytochemical with antiradiation and chemopreventative effects -
GC12649
TW-37
N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺,TW37,TW 37
An inhibitor of the Bcl-2 family proteins -
GC15084
2-Methoxyestradiol (2-MeOE2)
二甲氧基雌二醇; 2-ME2; NSC-659853
2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂。 -
GN10421
Kaempferol
山奈酚,Kempferol
Kaempferol是一种黄酮类化合物,可作为ERRα和ERRγ的反向激动剂,具有抗氧化、抗炎和抗肿瘤活性。 -
GC15878
Atractyloside Dipotassium Salt
苍术苷钾盐
Inhibitor of ADP/ATP translocases -
GC12961
Apicidin
OSI 2040
A cell-permeable HDAC inhibitor