Apoptosis Inducers(细胞凋亡诱导剂)
Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.
- Cat.No. 产品名称 Information
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GC16037
7BIO
A caspase-independent (nonapoptotic) cell death inducer
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GC14791
F16
A potential antitumor agent
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GC13034
ML-291
An activator of apoptosis through UPR
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GC14847
Psoralidin
A furanocoumarin with anti-cancer activity
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GC16375
(±)-Jasmonic Acid methyl ester
A plant growth regulator
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GC11988
15-acetoxy Scirpenol
A trichothecene mycotoxin
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GC10661
Destruxin B
An insecticidal mycotoxin
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GC16661
Citrinin
A mycotoxin with diverse biological activities
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GC14050
MPI-0441138
A potent inducer of apoptosis and growth inhibition
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GC11834
Epibrassinolide
A brassinosteroid with protective effects
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GC15036
Raltegravir potassium salt
An HIV-1 integrase inhibitor
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GC11710
CFM 4
CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合,导致 G2M 细胞周期停滞,并诱导细胞凋亡,IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
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GC15035
PM00104
Potent antimyeloma agent
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GC14312
Meisoindigo
An anticancer agent
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GC10744
Bendamustine HCl
A DNA alkylating agent
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GC15503
NSC 687852 (b-AP15)
An inhibitor of the deubiquitinases USP14 and UCHL5
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GC12353
Mitomycin C
Mitomycin C是一种抗生素,从Streptomyces caespitosus或Streptomyces lavendulae中分离出来。它通过与DNA形成共价的mitomycin C-DNA加合物来抑制DNA合成,在PC3细胞中的EC50值为0.14μM。
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GC17131
Streptozocin
A diabetogenic agent which targets beta cells
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GC10315
Plumbagin
A natural naphthoquinone
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GC10282
Piperlongumine
An alkaloid with anticancer and antioxidant activities
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GC14860
Oncrasin 1
An anticancer agent
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GC15484
Deguelin
A potent antiproliferative rotenoid compound
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GC17969
CHM 1
An inhibitor of tubulin polymerization
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GC16866
Actinomycin D
一种具有抗癌活性的DNA相互作用转录阻断剂。
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GC12258
2,3-DCPE hydrochloride
2,3-DCPE 是一种促凋亡化合物,对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
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GC18044
Trabectedin
An alkaloid with anticancer activity
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GC16055
SMIP004
SMIP004 是一种 SKP2 E3 连接酶抑制剂,可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。
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GC12857
R1530
A multi-kinase inhibitor
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GC17874
Matrine
An alkaloid with diverse biological activities
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GC12139
Gambogic Acid
A xanthonoid with anticancer activity
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GC14787
Curcumin
A yellow pigment with diverse biological activities
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GC16116
Costunolide
A natural sesquiterpene lactone
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GC14065
Capsaicin
A terpene alkaloid with diverse biological activities
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GC11632
Brassinolide
A plant growth regulator
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GC10480
Betulinic acid
A plant triterpenoid similar to bile acids
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GC12053
BAM7
A direct activator of Bax
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GC12791
3,3'-Diindolylmethane
A phytochemical with antiradiation and chemopreventative effects
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GC12649
TW-37
An inhibitor of the Bcl-2 family proteins
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GC15084
2-Methoxyestradiol (2-MeOE2)
A natural metabolite of estradiol
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GN10421
Kaempferol
A dietary flavonoid
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GC15878
Atractyloside Dipotassium Salt
Inhibitor of ADP/ATP translocases
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GC12961
Apicidin
A cell-permeable HDAC inhibitor