Apoptosis Inducers(细胞凋亡诱导剂)
Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.
Products for Apoptosis Inducers
- Cat.No. 产品名称 Information
- GC16037 7BIO A caspase-independent (nonapoptotic) cell death inducer
- GC14791 F16 A potential antitumor agent
- GC13034 ML-291 An activator of apoptosis through UPR
- GC14847 Psoralidin A furanocoumarin with anti-cancer activity
- GC16375 (±)-Jasmonic Acid methyl ester A plant growth regulator
- GC11988 15-acetoxy Scirpenol A trichothecene mycotoxin
- GC10661 Destruxin B An insecticidal mycotoxin
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GC16661
Citrinin
A mycotoxin with diverse biological activities
- GC14050 MPI-0441138 A potent inducer of apoptosis and growth inhibition
- GC11834 Epibrassinolide A brassinosteroid with protective effects
- GC15036 Raltegravir potassium salt An HIV-1 integrase inhibitor
- GC11710 CFM 4 CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合,导致 G2M 细胞周期停滞,并诱导细胞凋亡,IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
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GC15035
PM00104
Potent antimyeloma agent
- GC14312 Meisoindigo An anticancer agent
- GC10744 Bendamustine HCl A DNA alkylating agent
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GC17198
Cycloheximide
环丙沙星是一种抗生素,它在翻译水平上抑制蛋白质合成。
- GC15503 NSC 687852 (b-AP15) An inhibitor of the deubiquitinases USP14 and UCHL5
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GC12353
Mitomycin C
Mitomycin C是一种抗生素,从链霉菌(Streptomyces Caespitosus)或淡紫色链霉菌(Streptomyces Lavendulae)中分离出来。Mitomycin C通过与DNA形成共价mitomycin C-DNA加合物来抑制DNA合成,在PC3细胞中的EC50值为0.14μM。
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GC17131
Streptozocin
A diabetogenic agent which targets beta cells
- GC10315 Plumbagin A natural naphthoquinone
- GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
- GC14860 Oncrasin 1 An anticancer agent
- GC15484 Deguelin A potent antiproliferative rotenoid compound
- GC17969 CHM 1 An inhibitor of tubulin polymerization
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GC16866
Actinomycin D
一种具有抗癌活性的DNA相互作用转录阻断剂。
- GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物,对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
- GC18044 Trabectedin An alkaloid with anticancer activity
- GC16055 SMIP004 SMIP004 是一种 SKP2 E3 连接酶抑制剂,可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。
- GC12857 R1530 A multi-kinase inhibitor
- GC17874 Matrine An alkaloid with diverse biological activities
- GC12139 Gambogic Acid A xanthonoid with anticancer activity
- GC14787 Curcumin A yellow pigment with diverse biological activities
- GC16116 Costunolide A natural sesquiterpene lactone
- GC14065 Capsaicin A terpene alkaloid with diverse biological activities
- GC11632 Brassinolide A plant growth regulator
- GC10480 Betulinic acid A plant triterpenoid similar to bile acids
- GC12053 BAM7 A direct activator of Bax
- GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects
- GC12649 TW-37 An inhibitor of the Bcl-2 family proteins
- GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂,抑制HIF-1α核积累以及HIF转录活性。2-Methoxyestradiol可触发p53诱导的细胞凋亡, 具有潜在的抗肿瘤活性。.
- GN10421 Kaempferol A dietary flavonoid
- GC15878 Atractyloside Dipotassium Salt Inhibitor of ADP/ATP translocases
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GC12961
Apicidin
A cell-permeable HDAC inhibitor