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Apoptosis Inducers(细胞凋亡诱导剂)

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

  1. Cat.No. 产品名称 Information
  2. GC16037 7BIO A caspase-independent (nonapoptotic) cell death inducer
  3. GC14791 F16 A potential antitumor agent
  4. GC13034 ML-291 An activator of apoptosis through UPR
  5. GC14847 Psoralidin A furanocoumarin with anti-cancer activity
  6. GC16375 (±)-Jasmonic Acid methyl ester A plant growth regulator
  7. GC11988 15-acetoxy Scirpenol A trichothecene mycotoxin
  8. GC10661 Destruxin B An insecticidal mycotoxin
  9. GC16661 Citrinin

    A mycotoxin with diverse biological activities

  10. GC14050 MPI-0441138 A potent inducer of apoptosis and growth inhibition
  11. GC11834 Epibrassinolide A brassinosteroid with protective effects
  12. GC15036 Raltegravir potassium salt An HIV-1 integrase inhibitor
  13. GC11710 CFM 4 CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合,导致 G2M 细胞周期停滞,并诱导细胞凋亡,IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
  14. GC15035 PM00104

    Potent antimyeloma agent

  15. GC14312 Meisoindigo An anticancer agent
  16. GC10744 Bendamustine HCl A DNA alkylating agent
  17. GC17198 Cycloheximide

    环丙沙星是一种抗生素,它在翻译水平上抑制蛋白质合成。

  18. GC15503 NSC 687852 (b-AP15) An inhibitor of the deubiquitinases USP14 and UCHL5
  19. GC12353 Mitomycin C

    Mitomycin C是一种抗生素,从Streptomyces caespitosus或Streptomyces lavendulae中分离出来。它通过与DNA形成共价的mitomycin C-DNA加合物来抑制DNA合成,在PC3细胞中的EC50值为0.14μM。

  20. GC17131 Streptozocin

    A diabetogenic agent which targets beta cells

  21. GC10315 Plumbagin A natural naphthoquinone
  22. GC10282 Piperlongumine An alkaloid with anticancer and antioxidant activities
  23. GC14860 Oncrasin 1 An anticancer agent
  24. GC15484 Deguelin A potent antiproliferative rotenoid compound
  25. GC17969 CHM 1 An inhibitor of tubulin polymerization
  26. GC16866 Actinomycin D

    一种具有抗癌活性的DNA相互作用转录阻断剂。

  27. GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物,对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
  28. GC18044 Trabectedin An alkaloid with anticancer activity
  29. GC16055 SMIP004 SMIP004 是一种 SKP2 E3 连接酶抑制剂,可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。
  30. GC12857 R1530 A multi-kinase inhibitor
  31. GC17874 Matrine An alkaloid with diverse biological activities
  32. GC12139 Gambogic Acid A xanthonoid with anticancer activity
  33. GC14787 Curcumin A yellow pigment with diverse biological activities
  34. GC16116 Costunolide A natural sesquiterpene lactone
  35. GC14065 Capsaicin A terpene alkaloid with diverse biological activities
  36. GC11632 Brassinolide A plant growth regulator
  37. GC10480 Betulinic acid A plant triterpenoid similar to bile acids
  38. GC12053 BAM7 A direct activator of Bax
  39. GC12791 3,3'-Diindolylmethane A phytochemical with antiradiation and chemopreventative effects
  40. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins
  41. GC15084 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂,抑制HIF-1α核积累以及HIF转录活性。2-Methoxyestradiol可触发p53诱导的细胞凋亡, 具有潜在的抗肿瘤活性。.
  42. GN10421 Kaempferol A dietary flavonoid
  43. GC15878 Atractyloside Dipotassium Salt Inhibitor of ADP/ATP translocases
  44. GC12961 Apicidin

    A cell-permeable HDAC inhibitor

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