Apoptosis Inducers(细胞凋亡诱导剂)

Apoptosis, a programmed cell death to eliminate damaged or abnormal cells, is a highly organized physiological process characterized by condensation of nuclear heterochromatin, cell shrinkage and loss of positional organization of organelles in the cytoplasm. Apoptosis inducers are a collection of compounds that are capable of inducing apoptosis in cells. Apoptosis has been extensively studied in numerous researches, where induction of apoptosis has been associated with a variety of events, including activation of p53 gene, transcription factor NF-κB or caspases. Apoptosis inducers have the potential to be incorporated into the management and therapy or prevention of cancer for their ability to induce apoptosis in cancer cells.

Products for Apoptosis Inducers

Cat.No. 产品名称 Information
GC16037 7BIO
7-Bromoindirubin-3’-oxime
A caspase-independent (nonapoptotic) cell death inducer
GC14791 F16 A potential antitumor agent
GC13034 ML-291 An activator of apoptosis through UPR
GC14847 Psoralidin
补骨脂定
A furanocoumarin with anti-cancer activity
GC16375 (±)-Jasmonic Acid methyl ester
甲基茉莉酮酸酯,(±)-Methyl Jasmonate
A plant growth regulator
GC11988 15-acetoxy Scirpenol
15-乙酰蛇形菌素
A trichothecene mycotoxin
GC10661 Destruxin B
黑僵菌素 B
An insecticidal mycotoxin
GC16661 Citrinin
桔霉素; NSC 186
Citrinin是一种具有多种生物活性的霉菌毒素，由青霉属、曲霉属和红曲霉属的几种真菌菌株产生。
GC14050 MPI-0441138
EP128265
A potent inducer of apoptosis and growth inhibition
GC11834 Epibrassinolide
表油菜素内酯; 24-Epibrassinolide; B1105; BP55
A brassinosteroid with protective effects
GC15036 Raltegravir potassium salt
雷特格韦钾盐; MK 0518 potassium
An HIV-1 integrase inhibitor
GC11710 CFM 4 CFM 4 是 CARP-1/APC-2 结合的有效小分子拮抗剂。 CFM 4 阻止 CARP-1 与 APC-2 结合，导致 G2M 细胞周期停滞，并诱导细胞凋亡，IC50 范围为 10-15 μM. CFM 4 还抑制耐药人类乳腺癌细胞的生长。
GC15035 PM00104
Potent antimyeloma agent
GC14312 Meisoindigo
甲异靛; Dian III; N-Methylisoindigotin; Natura-α
An anticancer agent
GC10744 Bendamustine HCl
盐酸苯达莫司汀; SDX-105
A DNA alkylating agent
GC17198 Cycloheximide
Naramycin A; Actidione; 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide

环丙沙星是一种抗生素，它在翻译水平上抑制蛋白质合成。
GC15503 NSC 687852 (b-AP15)
b-AP15
An inhibitor of the deubiquitinases USP14 and UCHL5
GC12353 Mitomycin C
丝裂霉素 C,Ametycine

Mitomycin C是一种抗生素，从链霉菌（Streptomyces Caespitosus）或淡紫色链霉菌（Streptomyces Lavendulae）中分离出来。Mitomycin C通过与DNA形成共价mitomycin C-DNA加合物来抑制DNA合成，在PC3细胞中的EC50值为0.14μM。
GC17131 Streptozocin
链脲佐菌素; Streptozotocin; U 9889

A diabetogenic agent which targets beta cells
GC10315 Plumbagin
白花丹素; 2-Methyljuglone
A natural naphthoquinone
GC10282 Piperlongumine
荜茇酰胺; Piplartine
An alkaloid with anticancer and antioxidant activities
GC14860 Oncrasin 1
1-(4-氯苄基)-1H-吲哚-3-甲醛
An anticancer agent
GC15484 Deguelin
鱼藤素; (-)-Deguelin; (-)-cis-Deguelin
A potent antiproliferative rotenoid compound
GC17969 CHM 1
NSC656158
An inhibitor of tubulin polymerization
GC16866 Actinomycin D
放线菌素D,DACTINOMYCIN

一种具有抗癌活性的DNA相互作用转录阻断剂。
GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物，对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
GC18044 Trabectedin
曲贝替定; Ecteinascidin 743; ET-743
An alkaloid with anticancer activity
GC16055 SMIP004
N-(4-丁基-2-甲基苯基)乙酰胺,SMIP 004;SMIP-004
SMIP004 是一种 SKP2 E3 连接酶抑制剂，可下调 SKP2 并稳定 p27。 SMIP004 是人前列腺癌细胞的癌细胞选择性凋亡诱导剂。
GC12857 R1530
5-(2-氯苯基)-7-氟-1,2-二氢-8-甲氧基-3-甲基吡唑并[3,4-B][1,4]苯并二氮杂卓,R 1530;R-1530
A multi-kinase inhibitor
GC17874 Matrine
苦参碱; Matridin-15-one; Vegard; α-Matrine
An alkaloid with diverse biological activities
GC12139 Gambogic Acid
藤黄酸; Beta-Guttiferrin
A xanthonoid with anticancer activity
GC14787 Curcumin
姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow
A yellow pigment with diverse biological activities
GC16116 Costunolide
木香烃内酯; (+)-Costunolide; Costus lactone
A natural sesquiterpene lactone
GC14065 Capsaicin
辣椒素; (E)-Capsaicin
A terpene alkaloid with diverse biological activities
GC11632 Brassinolide
油菜素内酯; Brassin lactone
A plant growth regulator
GC10480 Betulinic acid
白桦脂酸; Lupatic acid; Betulic acid
A plant triterpenoid similar to bile acids
GC12053 BAM7
BAM 7;BAM-7
A direct activator of Bax
GC12791 3,3'-Diindolylmethane
3,3'-二吲哚甲烷,diindolylmethane, 3,3'-Methylenediindole,DIM,Arundine,HB236
A phytochemical with antiradiation and chemopreventative effects
GC12649 TW-37
N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺,TW37,TW 37
An inhibitor of the Bcl-2 family proteins
GC15084 2-Methoxyestradiol (2-MeOE2)
二甲氧基雌二醇; 2-ME2; NSC-659853
2-Methoxyestradiol (2-MeOE2/2-Me)是一种HIF-1α抑制剂,抑制HIF-1α核积累以及HIF转录活性。2-Methoxyestradiol可触发p53诱导的细胞凋亡, 具有潜在的抗肿瘤活性。.
GN10421 Kaempferol
山奈酚,Kempferol
A dietary flavonoid
GC15878 Atractyloside Dipotassium Salt
苍术苷钾盐
Inhibitor of ADP/ATP translocases
GC12961 Apicidin
OSI 2040

A cell-permeable HDAC inhibitor