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(R,S)-Anatabine Sale

(Synonyms: 新烟草碱(去氢新烟碱)) 目录号 : GC16032

A minor tobacco alkaloid

(R,S)-Anatabine Chemical Structure

Cas No.:2743-90-0

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥297.00
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10mg
¥270.00
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25mg
¥540.00
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50mg
¥855.00
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100mg
¥1,368.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Anatabine, an alkaloid with a chemical structural similarity to nicotine, is a minor tobacco alkaloid produced in plants of the Solanacea family including tobacco, green tomatoes, peppers and eggplants [1]. (R,S)-Anatabine is an Aβ inhibitor [1].

Aβ peptides play a dominant role in the development of Alzheimer's disease. Natural soluble Aβ oligomers and more specifically Aβ dimers isolated from Alzheimer's disease brains have been involved in inducing tau hyperphosphorylation and neuritic degeneration, which results in the accumulation of Aβ oligomers to the neurofibrillary degeneration observed in Alzheimer's disease [1].

In vitro: Anatabine dose-dependently lowered Aβ1-40 and Aβ1-42 levels and reduced sAPPβ production without any effects on sAPPα levels. Anatabine lowered Aβ production by mainly impacting the β-cleavage of APP. Anatabine lowered NFκB activation. Anatabine inhibited BACE-1 transcription and reduced BACE-1 protein levels in human neuronal like SHSY-5Y cells. (R,S)-Anatabine also dose dependently inhibits NF-κB activation [1].

In vivo: In a transgenic mouse model of Alzheimer's disease, acute treatment with anatabine for 4 days significantly lowered brain soluble Aβ1-40 and Aβ1-42 levels [1].

Reference:
[1] Paris D, Beaulieu-Abdelahad D, Bachmeier C, et al.  Anatabine lowers Alzheimer's Aβ production in vitro and in vivo[J]. European journal of pharmacology, 2011, 670(2): 384-391.

Chemical Properties

Cas No. 2743-90-0 SDF
别名 新烟草碱(去氢新烟碱)
化学名 1,2,3,6-tetrahydro-2,3'-bipyridine
Canonical SMILES [C@@H]1(C2=CN=CC=C2)CC=CCN1
分子式 C10H12N2 分子量 160.2
溶解度 ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 6.2422 mL 31.211 mL 62.422 mL
5 mM 1.2484 mL 6.2422 mL 12.4844 mL
10 mM 0.6242 mL 3.1211 mL 6.2422 mL
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