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Pyrazinamide Sale

(Synonyms: 吡嗪酰胺; Pyrazinecarboxamide; Pyrazinoic acid amide) 目录号 : GC13843

An antimycobacterial compound

Pyrazinamide Chemical Structure

Cas No.:98-96-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥350.00
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10mg
¥450.00
现货
50mg
¥855.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.Target: AntibacterialPyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, necessary for survival of M. tuberculosis at an acidic site of infection. Pyrazinoic acid binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. This may explain the ability of the drug to kill dormant mycobacteria [1-4].

References:
[1]. Zhang, Y. and D. Mitchison, The curious characteristics of pyrazinamide: a review. Int J Tuberc Lung Dis, 2003. 7(1): p. 6-21.
[2]. Zimhony, O., et al., Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat Med, 2000. 6(9): p. 1043-7.
[3]. Boshoff, H.I., V. Mizrahi, and C.E. Barry, 3rd, Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I. J Bacteriol, 2002. 184(8): p. 2167-72.
[4]. Shi, W., et al., Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science, 2011. 333(6049): p. 1630-2.

Chemical Properties

Cas No. 98-96-4 SDF
别名 吡嗪酰胺; Pyrazinecarboxamide; Pyrazinoic acid amide
化学名 pyrazine-2-carboxamide
Canonical SMILES C1=CN=C(C=N1)C(=O)N
分子式 C5H5N3O 分子量 123.11
溶解度 ≥ 5.35mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 8.1228 mL 40.6141 mL 81.2282 mL
5 mM 1.6246 mL 8.1228 mL 16.2456 mL
10 mM 0.8123 mL 4.0614 mL 8.1228 mL
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