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Stearoyl-L-carnitine-d3 (chloride) Sale

(Synonyms: CAR 18:0-d3, C18:0 Carnitine-d3, L-Carnitine octdecanoyl ester-d3, L-Carnitine stearoyl ester-d3, L-Octadecanoylcarnitine-d3, Octadecanoyl-L-carnitine-d3, L-Stearoylcarnitine-d3, R-Stearoyl carnitine-d3) 目录号 : GC48107

An internal standard for the quantification of stearoyl-L-carnitine

Stearoyl-L-carnitine-d3 (chloride) Chemical Structure

Cas No.:2245711-27-5

规格 价格 库存 购买数量
500 μg
¥839.00
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1 mg
¥1,593.00
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5 mg
¥3,786.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Stearoyl-L-carnitine-d3 (chloride) is intended for use as an internal standard for the quantification of stearoyl-L-carnitine by GC- or LC-MS. Stearoyl-L-carnitine is a naturally occurring long-chain acylcarnitine.1 It inhibits sodium-dependent [3H]carnitine uptake in human proximal convoluted tubular (HPCT) cells by 52% when used at a concentration of 500 μM.2 It also inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma when used at a concentration of 500 µM.3 Plasma levels of stearoyl-L-carnitine are decreased in patients with chronic fatigue syndrome and increased in patients with end-stage renal disease.4,1

1.Reuter, S.E., Evans, A.M., Faull, R.J., et al.Impact of haemodialysis on individual endogenous plasma acylcarnitine concentrations in end-stage renal diseaseAnn. Clin. Biochem.42(Pt 5)387-393(2005) 2.Huang, W., Shaikh, S.N., Ganapathy, M.E., et al.Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cellsBiochem. Pharmacol.58(8)1361-1370(1999) 3.Bell, F.P.Carnitine esters: Novel inhibitors of plasma lecithin: Cholesterol acyltransferase in experimental animals but not in man (Homo sapiens)Int. J. Biochem.15(2)133-136(1983) 4.Reuter, S.E., and Evans, A.M.Long-chain acylcarnitine deficiency in patients with chronic fatigue syndrome. Potential involvement of altered carnitine palmitoyltransferase-I activityJ. Intern. Med.270(1)76-84(2011)

Chemical Properties

Cas No. 2245711-27-5 SDF
别名 CAR 18:0-d3, C18:0 Carnitine-d3, L-Carnitine octdecanoyl ester-d3, L-Carnitine stearoyl ester-d3, L-Octadecanoylcarnitine-d3, Octadecanoyl-L-carnitine-d3, L-Stearoylcarnitine-d3, R-Stearoyl carnitine-d3
Canonical SMILES OC(C[C@H](C[N+](C([2H])([2H])[2H])(C)C)OC(CCCCCCCCCCCCCCCCC)=O)=O.[Cl-]
分子式 C25H47D3NO4.Cl 分子量 467.1
溶解度 DMF: 20 mg/ml,DMSO: 14 mg/ml,Ethanol: 20 mg/ml 储存条件 Store at -20°C
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1 mM 2.1409 mL 10.7043 mL 21.4087 mL
5 mM 0.4282 mL 2.1409 mL 4.2817 mL
10 mM 0.2141 mL 1.0704 mL 2.1409 mL
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Research Update

A Quick Reference on chloride

Vet Clin North Am Small Anim Pract 2017 Mar;47(2):219-222.PMID:28007306DOI:10.1016/j.cvsm.2016.10.008.

chloride is an essential element, playing important roles in digestion, muscular activity, regulation of body fluids, and acid-base balance. As the most abundant anion in extracellular fluid, chloride plays a major role in maintaining electroneutrality. chloride is intrinsically linked to sodium in maintaining osmolality and fluid balance and has an inverse relationship with bicarbonate in maintaining acid-base balance. It is likely because of these close ties that chloride does not get the individual attention it deserves; we can use these facts to simplify and interpret changes in serum chloride concentrations.

Development and biological applications of chloride-sensitive fluorescent indicators

Am J Physiol 1990 Sep;259(3 Pt 1):C375-88.PMID:2205105DOI:10.1152/ajpcell.1990.259.3.C375.

chloride movement across cell plasma and internal membranes, is of central importance for regulation of cell volume and pH, vectorial salt movement in epithelia, and, probably, intracellular traffic. Quinolinium-based chloride-sensitive fluorescent indicators provide a new approach to study chloride transport mechanisms and regulation that is complementary to 36Cl tracer methods, intracellular microelectrodes, and patch clamp. Indicator fluorescence is quenched by chloride by a collisional mechanism with Stern-Volmer constants of up to 220 M-1. Fluorescence is quenched selectively by chloride in physiological systems and responds to changes in chloride concentration in under 1 ms. The indicators are nontoxic and can be loaded into living cells for continuous measurement of intracellular chloride concentration by single-cell fluorescence microscopy. In this review, the structure-activity relationships for chloride-sensitive fluorescent indicators are described. Methodology for measurement of chloride transport in isolated vesicle and liposome systems and in intact cells is evaluated critically by use of examples from epithelial cell physiology. Future directions for synthesis of tailored chloride-sensitive indicators and new applications of indicators for studies of transport regulation and intracellular ion gradients are proposed.

chloride toxicity in critically ill patients: What's the evidence?

Anaesth Crit Care Pain Med 2017 Apr;36(2):125-130.PMID:27476827DOI:10.1016/j.accpm.2016.03.008.

Crystalloids have become the fluid of choice in critically ill patients and in the operating room both for fluid resuscitation and fluid maintenance. Among crystalloids, NaCl 0.9% has been the most widely used fluid. However, emerging evidence suggests that administration of 0.9% saline could be harmful mainly through high chloride content and that the use of fluid with low chloride content may be preferable in major surgery and intensive care patients. Administration of NaCl 0.9% is the leading cause of metabolic hyperchloraemic acidosis in critically ill patients and side effects might target coagulation, renal function, and ultimately increase mortality. More balanced solutions therefore may be used especially when large amount of fluids are administered in high-risk patients. In this review, we discuss physiological background favouring the use of balanced solutions as well as the most recent clinical data regarding the use of crystalloid solutions in critically ill patients and patients undergoing major surgery.

Salt reduction in vegetable fermentation: reality or desire?

J Food Sci 2013 Aug;78(8):R1095-100.PMID:23772964DOI:10.1111/1750-3841.12170.

NaCl is a widely used chemical in food processing which affects sensory characteristics and safety; in fact, its presence is frequently essential for the proper preservation of the products. Because the intake of high contents of sodium is linked to adverse effects on human health, consumers demand foods with low-sodium content. A 1st step to reduce the use of salt would imply the proper application of this compound, reducing its levels to those technologically necessary. In addition, different chloride salts have been evaluated as replacers for NaCl, but KCl, CaCl2 , and ZnCl2 show the most promising perspectives of use. However, prior to any food reformulation, there is a need for exhaustive research before its application at industrial level. Salt reduction may lead to an increased risk in the survival/ growth of pathogens and may also alter food flavor and cause economic losses. This review deals with the technological, microbiological, sensorial, and health aspects of the potential low-salt and salt-substituted vegetable products and how this important segment of the food industry is responding to consumer demand.

CMBEAR: Python-Based Recharge Estimator Using the chloride Mass Balance Method in Australia

Ground Water 2022 May;60(3):418-425.PMID:34919277DOI:10.1111/gwat.13161.

The chloride mass balance (CMB) method is widely used to estimate long-term rates of groundwater recharge. In regions where surface water runoff is negligible, recharge can be estimated using measurements of chloride concentrations of groundwater and precipitation, and an estimate of long-term average rainfall. This paper presents the chloride Mass Balance Estimator of Australian Recharge (CMBEAR), a Jupyter (Python) Notebook that is set up to rapidly apply the CMB method using gridded maps of chloride deposition rates across the Australian continent. For an Australian context, the chloride deposition rate and rainfall maps have been provided. Thus, CMBEAR requires only a spreadsheet with the groundwater chloride concentration, the latitude and longitude of the sample location, and some simple user inputs. CMBEAR may be easily applied in other regions, providing that a gridded chloride deposition map is available. Recharge estimates from CMBEAR are compared against published applications of the CMB method. CMBEAR is also applied to a large dataset from the Northern Territory and is used to produce a gridded map of recharge for western Victoria. CMBEAR provides a reproducible and straightforward approach to apply the CMB method to estimate groundwater recharge.