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Aurora Kinase(极光激酶)

  1. Cat.No. 产品名称 Information
  2. GC62433 AKI603 AKI-603 is an inhibitor of Aurora kinase A (AurA), which is developed to overcome resistance mediated by BCR-ABL-T315I mutation.
  3. GP22424 AURKA Human Aurora Kinase A Human Recombinant
  4. GP22425 AURKB Human Aurora Kinase B Human Recombinant
  5. GC40667 Aurora Kinase Inhibitor II

    4-(4-Benzamidoanilino)-6,7-dimethoxyquinazoline

    Blocks Aurora A kinase activity
  6. GC67899 Aurora kinase inhibitor-8 Aurora kinase inhibitor-8 是一种高选择性 Aurora 激酶的抑制剂。
  7. GC62189 CD532 hydrochloride An inhibitor of Aurora A kinase activity and the Aurora A-N-Myc protein-protein interaction
  8. GC62145 Chiauranib

    CS2164

    Chiauranib (CS2164) selectively inhibits multiple kinase targets aurora B kinase (AURKB), colony-stimulating factor 1 receptor (CSF1R), and vascular endothelial growth factor receptor (VEGFR)/platelet-derived growth factor receptor (PDGFR)/c-Kit , thereby inhibiting the rapid proliferation of tumor cells, enhancing the antitumor immunity, and inhibiting tumor angiogenesis, to achieve the anti-tumor efficacy.
  9. GC68147 dAURK-4 hydrochloride dAURK-4 hydrochloride 是 Alisertib 的一种衍生物,是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 hydrochloride 具有抗癌作用。
  10. GC69068 ENMD-2076 Tartrate ENMD-2076 Tartrate 是多靶点激酶抑制剂,抑制 Aurora A,Flt3,KDR/VEGFR2,Flt4/VEGFR3,FGFR1,FGFR2,Src,PDGFRα 的IC50 值分别为1.86,14,58.2,15.9,92.7,70.8,20.2 and 56.4 nM。
  11. GC50050 Hesperadin hydrochloride A multi-kinase inhibitor
  12. GC25940 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. It is less potent to Trk A/B, Flt4, Fms, Axl, c-Raf and DDR2. Phase 1.
  13. GC62482 TAS-119 TAS-119 是一种有效的,选择性的,具有口服活性的 Aurora A 抑制剂,IC50 为 1.0 nM。TAS-119 对 Aurora A 的选择性高于其他蛋白激酶,包括 Aurora B (IC50 为 95 nM)。TAS-119 具有有效的抗肿瘤活性。
  14. GC70030 Tinengotinib Tinengotinib 是一种或多种蛋白激酶的调节剂,例如 Aurora 激酶和 VEGFR 激酶。Tinengotinib 具有研究这些激酶异常介导的疾病的潜力,尤其是癌症相关疾病 (摘自专利 WO2018108079A1)。

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