PNPT1 Human
目录号 : GP22124Polyribonucleotide Nucleotidyltransferase 1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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PNPT1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 761 amino acids (46-783 a.a) and having amolecular mass of 83.3kDa.PNPT1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Polyribonucleotide Nucleotidyltransferase 1; PolynucleotidePhosphorylase-Like Protein; Polynucleotide Phosphorylase 1; 3-5 RNA ExonucleaseOLD35; PNPase Old-35; EC 2.7.7.8; PNPase 1; COXPD13; DFNB70; PNPASE; OLD35; PolyribonucleotideNucleotidyltransferase 1; Mitochondrial; Deafness; Autosomal Recessive 70; PolynucleotidePhosphorylase; 3-5 RNA Exonuclease; EC 2.7.7; Old-35; Polyribonucleotidenucleotidyltransferase 1; mitochondrial; 3'-5' RNA exonuclease OLD35; PNPaseold-35. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSAVAVDLG NRKLEISSGK LARFADGSAV VQSGDTAVMV TAVSKTKPSPSQFMPLVVDY RQKAAAAGRI PTNYLRREIG TSDKEILTSR IIDRSIRPLF PAGYFYDTQV LCNLLAVDGVNEPDVLAING ASVALSLSDI PWNGPVGAVR IGIIDGEYVV NPTRKEMSSS TLNLVVAGAP KSQIVMLEASAENILQQDFC HAIKVGVKYT QQIIQGIQQL VKETGVTKRT PQKLFTPSPE IVKYTHKLAM ERLYAVFTDYEHDKVSRDEA VNKIRLDTEE QLKEKFPEAD PYEIIESFNV VAKEVFRSIV LNEYKRCDGR DLTSLRNVSCEVDMFKTLHG SALFQRGQTQ VLCTVTFDSL ESGIKSDQVI TAINGIKDKN FMLHYEFPPY ATNEIGKVTGLNRRELGHGA LAEKALYPVI PRDFPFTIRV TSEVLESNGS SSMASACGGS LALMDSGVPI SSAVAGVAIGLVTKTDPEKG EIEDYRLLTD ILGIEDYNGD MDFKIAGTNK GITALQADIK LPGIPIKIVM EAIQQASVAKKEILQIMNKT ISKPRASRKE NGPVVETVQV PLSKRAKFVG PGGYNLKKLQ AETGVTISQV DEETFSVFAPTPSAMHEARD FITEICKDDQ EQQLEFGAVY TATITEIRDT GVMVKLYPNM TAVLLHNTQL DQRKIKHPTALGLEVGQEIQ VKYFGRDPAD GRMRLSRKVL QSPATTVVRT LNDRSSIVMG EPISQSSSNS Q. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. | ||
| Formulation | PNPT1 protein solution (0.25mg/ml) containing Phosphatebuffered saline (pH7.4), 10% glycerol and 1mM DTT. | ||
Polyribonucleotide nucleotidyltransferase 1, also known as PNPT1 ispredominantly localized in the mitochondrial intermembrane space and is implicated inthe import of RNA to mitochondria. Mutations in PNPT1 have been connected withcombined oxidative phosphorylation deficiency-13 as well as autosomal recessivenonsyndromic deafness-70. Related pseudogenes have been found on chromosomes 3 & 7.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.