PDE6H Human
目录号 : GP22056Phosphodiesterase 6H cGMP-Specific Cone Gamma Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 80% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Phosphodiesterase 6H; CGMP-Specific; Cone; Gamma; RetinalCone Rhodopsin-Sensitive CGMP 3';5'-Cyclic Phosphodiesterase; Subunit Gamma; EC3.1.4.35; EC 3.1.4.17; RCD3; GMP-PDE Gamma; ACHM6; PDE6H. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSDNTTL PAPASNQGPT TPRKGPPKFK QRQTRQFKSK PPKKGVKGFGDDIPGMEGLG TDITVICPWE AFSHLELHEL AQFGII. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | PDE6H protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 2mM DTT and 0.1mM PMSF. | ||
PDE6Hbelongs to the rod/cone cGMP-PDE gamma subunit family, which selectivelycatalyze the hydrolysis of 3 cyclic phosphate bonds in adenosine and/or guanine3,5 cyclic monophosphate (cAMP and/or cGMP). This family regulates the cellularlevels, localization and duration of action of these second messengers bycontrolling the rate of their degradation. PDE6H is the inhibitory (or gamma)subunit of the cone-specific cGMP phosphodiesterase, which is a tetramercomposed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).PDE6H is particularly expressed in the retina, and is implicated in thetransmission and amplification of the visual signal. Mutations in PDE6H havebeen associated with retinal cone dystrophy type 3A.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.