NMNAT2 Human
目录号 : GP22004Nicotinamide Nucleotide Adenylyltransferase 2 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Nicotinamide Nucleotide Adenylyltransferase 2; C1orf15; Nicotinate-NucleotideAdenylyltransferase 2; NaMN Adenylyltransferase 2; NMN Adenylyltransferase 2; PNAT2;KIAA0479; Chromosome 1 Open Reading Frame 15; Nicotinamide MononucleotideAdenylyltransferase 2; Pyridine Nucleotide Adenylyltransferase 2; EC 2.7.7.1; EC2.7.7.18. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSHMTETTKTHVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL VSSRHRLIMCQLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP SMTPVIGQPQ NETPQPIYQNSNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA NLGTVMRYEE IELRILLLCG SDLLESFCIPGLWNEADMEV IVGDFGIVVV PRDAADTDRI MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHGDGHVVDYLSQ PVIDYILKSQ LYINASG | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Biological Activity | Specific activity: > 500 pmol/min/ug. One unit will convert 1.0 pmole of beta-NADH per minute to beta-NAD at PH 8.0 at 37°C . | ||
| Formulation | NMNAT2 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. | ||
NicotinamideNucleotide Adenylyltransferase 2, also known as NMNAT2 is a member of thenicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, membersof which catalyze a vital step in NAD (NADP) biosynthetic pathway. Unlike theother human family member, which is localized to the nucleus, and isubiquitously expressed; NMNAT2 is cytoplasmic, and is predominantlyexpressed in the brain. Two transcript variants encoding different isoformshave been found for NMNAT2. Among the diseases associated with NMNAT2 aretauopathy, and systemic lupus erythematosus.
Specific activity: > 500 pmol/min/ug. One unit will convert 1.0 pmole of beta-NADH per minute to beta-NAD at PH 8.0 at 37°C .
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.