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N-butyl Amphetamine (hydrochloride) Sale

(Synonyms: N-butyl-α-methyl-Phenethylamine) 目录号 : GC44331

An Analytical Reference Standard

N-butyl Amphetamine (hydrochloride) Chemical Structure

Cas No.:35892-11-6

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Sample solution is provided at 25 µL, 10mM.

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产品描述

N-butyl Amphetamine (hydrochloride) is an analytical reference standard categorized as an amphetamine. This product is intended for research and forensic applications.

Chemical Properties

Cas No. 35892-11-6 SDF
别名 N-butyl-α-methyl-Phenethylamine
Canonical SMILES CC(NCCCC)CC1=CC=CC=C1.Cl
分子式 C13H21N•HCl 分子量 227.8
溶解度 DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 5 mg/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 4.3898 mL 21.9491 mL 43.8982 mL
5 mM 0.878 mL 4.3898 mL 8.7796 mL
10 mM 0.439 mL 2.1949 mL 4.3898 mL
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Research Update

Characterisation of 5-HT2 receptor subtypes in the Suncus murinus intestine

Eur J Pharmacol 1999 Sep 24;381(2-3):161-9.PMID:10554884DOI:10.1016/s0014-2999(99)00562-2.

The involvement of 5-HT2 receptor subtypes in mediating a contraction response in the isolated intestine of Suncus murinus was investigated using DOI ((+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane, a 5-HT2 receptor agonist) which produced a bell-shaped concentration response curve that was significantly (p < 0.05) reduced by methysergide (a 5-HT1/2 receptor antagonist, 1 microM) but not ketanserin (a 5-HT2A receptor antagonist, 1 microM), yohimbine (a 5-HT2B receptor antagonist, 1 microM) or a combination of ondansetron (a 5-HT3 receptor antagonist, 1 microM) plus SB204070 (8-amino-7-chloro(N-butyl-4-piperidyl) methylbenzo-1,4-dioxan-5-carboxylate hydrochloride, a 5-HT4 receptor antagonist, 1 nM). The contraction response to the lower concentrations of DOI (10 nM-0.3 microM) was reduced in the presence of SB206553 (5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2 ,3-f]indole, a 5-HT2B/2C receptor antagonist, 1 microM), whilst conversely, the reducing response to the higher concentrations of DOI (1-30 microM) was prevented. A repeated challenge with 3 microM DOI produced a smaller response (desensitisation) and also reduced the response to 5-HT (5-hydroxytryptamine, 0.3 microM) that was inhibited by SB206553 (1 microM). Data indicate that 5-HT2C receptors are likely candidates to mediate the contractile response to DOI and demonstrate desensitisation to repeated challenges.

5-HT4 receptor antagonism does not affect motor and reward mechanisms in the rat

Eur J Pharmacol 1998 Sep 18;357(2-3):115-20.PMID:9797026DOI:10.1016/s0014-2999(98)00564-0.

5-HT4 receptors are concentrated in areas of the brain which are rich in dopamine neuronal markers, which may suggest that they influence motor and reward processes. We tested this hypothesis by examining the effects of a 5-HT4 receptor antagonist, 8-amino-7-chloro-(N-butyl-4-piperidyl)methylbenzo-1,4-dioxan-5-car boxylate hydrochloride (SB-204070-A) on amphetamine- and nicotine-induced locomotor stimulation in intact rats. In rats with unilateral 6-hydroxydopamine-induced lesions of the ascending nigrostriatal dopaminergic projection, SB-204070-A was tested for its effects on amphetamine-induced rotation. SB-204070-A was also tested for its effects on rewarded behaviour maintained by intracranial self-stimulation. SB-204070-A did not alter behaviour under any of these conditions, suggesting a lack of involvement of the 5-HT4 receptor in motor and reward processes.