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Misoprostol acid D5 Sale

目录号 : GC60248

Internal standard for the quantification of misoprostol (free acid)

Misoprostol acid D5 Chemical Structure

Cas No.:1337917-44-8

规格 价格 库存 购买数量
1mg
¥7,020.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

Misoprostol (free acid)-d5 contains five deuterium atoms at the 16 methyl, 17, and 17' positions. It is intended for use as an internal standard for the quantification of misoprostol (free acid) by GC- or LC-mass spectrometry (MS). Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors.1,2,3,4 It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 ?g/kg),2 inhibit superoxide generation in human neutrophils (EC50 = 0.35 ?M),3 and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM)4 in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with RU-486 for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid.1

1.Walt, R.P.Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulcerationN. Engl. J. Med.3271575-1580(1992) 2.Bunce, K.T., Clayton, N.M., Coleman, R.A., et al.GR63799X - a novel prostanoid with selectivity for EP3 receptorsAdv. Prostaglandin Thromboxane Leukot. Res.21(A)379-382(1990) 3.Talpain, E., Armstrong, R.A., Coleman, R.A., et al.Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophilsBr. J. Pharmacol.114(7)1459-1465(1995) 4.Smith, G.C.S., Coleman, R.A., and McGrath, J.C.Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosusJ. Pharmacol. Exp. Ther.271390-396(1994)

Chemical Properties

Cas No. 1337917-44-8 SDF
Canonical SMILES O[C@H]1[C@@H]([C@H](C(C1)=O)CCCCCCC(O)=O)/C=C/CC(C([2H])([2H])[2H])(O)C([2H])([2H])CCC
分子式 C21H31D5O5 分子量 373.54
溶解度 DMF: >100 mg/ml,DMSO: >50 mg/ml,Ethanol: >50 mg/ml,PBS pH 7.2: 1 mg/ml 储存条件
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

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1 mg 5 mg 10 mg
1 mM 2.6771 mL 13.3854 mL 26.7709 mL
5 mM 0.5354 mL 2.6771 mL 5.3542 mL
10 mM 0.2677 mL 1.3385 mL 2.6771 mL
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