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BMY-25271 Sale

目录号 : GC31877

BMY-25271是一个组胺H2受体(histamineH2receptor)拮抗剂。

BMY-25271 Chemical Structure

Cas No.:78441-82-4

规格 价格 库存
1mg
¥10,059.00
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5mg
¥16,092.00
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10mg
¥25,748.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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实验参考方法

Animal experiment:

Five beagle dogs are used in this study. Vehicle or BMY-25271 (0.4 mg/kg) is administered orally 1 h before aspirin (100 mg/kg). Blood samples are collected from the jugular vein just before aspirin administration and 30, 60, 90 and 120 min after aspirin administration. One week later, the dogs are crossed over, and the study is repeated[1].

References:

[1]. Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84.

产品描述

BMY-25271 is a histamine H2 receptor antagonist.

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED50 values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid[1].

[1]. Cavanagh RL, et al. Prevention of aspirin-induced gastric mucosal injury by histamine H2 receptor antagonists: a crossover endoscopic and intragastric pH study in the dog. J Pharmacol Exp Ther. 1987 Dec;243(3):1179-84.

Chemical Properties

Cas No. 78441-82-4 SDF
Canonical SMILES NC1=NS(N=C1NCCSCC2=CC=C(CN(C)C)O2)=O
分子式 C12H19N5O2S2 分子量 329.44
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.0355 mL 15.1773 mL 30.3545 mL
5 mM 0.6071 mL 3.0355 mL 6.0709 mL
10 mM 0.3035 mL 1.5177 mL 3.0355 mL
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