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L-Asparaginase

目录号 : GP21861

L-天冬酰胺酶(L-ASNase)是一种脱酰胺酶,催化L-天冬酰胺和L-谷氨酰胺的水解,可用于急性淋巴细胞白血病的研究。 L-天冬酰胺酶从血浆中消耗 L-天冬酰胺,导致 RNA 和 DNA 合成受到抑制,随后发生胚细胞凋亡。

L-Asparaginase Chemical Structure

规格 价格 库存 购买数量
500IU
¥840.00
5-10工作日
2500IU
¥2,030.00
5-10工作日
10000IU
¥5,600.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

L-Asparaginase was purified from E.coli ASI.357

Product Data

Purity Greater than 96.0% as determined bySDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Shipping Condition Shipped at Room temp.
Solubility It is recommended to reconstitute the lyophilized L-Asparaginase in 18M-cm H2O at 1mg/ml.
Stability Lyophilized L-Asparaginase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution L-Asparaginase should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.
Biological Activity One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 µmol of ammonia per minute at pH 7.3 and 37°C.
Formulation The enzyme was lyophilized with no additives.

Introduction

L-Asparaginase is an enzyme that depletes L-Asparagine "an important nutrient for cancer cells" resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli.,which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease.The rationale behind asparaginase is that it takes advantage of the fact that ALL cellsare unable to synthesize the non-essential amino acidasparaginewhereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine.

Biological Activity

One IU of L- Asparaginase is defined as that amount of enzyme required to generate 1 µmol of ammonia per minute at pH 7.3 and 37°C.

Stability

Lyophilized L-Asparaginase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution L-Asparaginase should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.