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L 601920-0 (Methyl-3β-hydroxycholenate) Sale

(Synonyms: 5-胆烯-24-酸-3Β-醇甲酯) 目录号 : GC32044

L 601920-0 (Methyl-3β-hydroxycholenate) 是一种从专利 US20110263046 A1 中提取的 ROR γ 调节剂,如图 2 所示。

L 601920-0 (Methyl-3β-hydroxycholenate) Chemical Structure

Cas No.:20231-57-6

规格 价格 库存 购买数量
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Sample solution is provided at 25 µL, 10mM.

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产品描述

L 601920-0 is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.

[1]. Deuschle, Ulrich, et al. Methods of identification of novel ligands for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (NR1F3) activity. US20110263046A1.

Chemical Properties

Cas No. 20231-57-6 SDF
别名 5-胆烯-24-酸-3Β-醇甲酯
Canonical SMILES C[C@H](CCC(OC)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
分子式 C25H40O3 分子量 388.58
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5735 mL 12.8674 mL 25.7347 mL
5 mM 0.5147 mL 2.5735 mL 5.1469 mL
10 mM 0.2573 mL 1.2867 mL 2.5735 mL
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Research Update

4-[18F]Fluoro-2-D-methyl-3-mercaptopropanoyl-L-proline

The renin–angiotensin system (RAS) plays a very important role in blood pressure regulation (1-4) in humans. Renin is an enzyme produced in the kidneys and it cleaves circulating angiotensinogen (a protein produced in the liver) to yield angiotensin I, an inactive decapeptide. The angiotensin-converting enzyme (ACE), found primarily in the lung, converts angiotensin I to angiotensin II, an active vasoconstrictor octapeptide. Angiotensin II also stimulates the production of aldosterone from the adrenal glands that promotes sodium and water retention. ACE is also responsible for inactivating bradykinin, a vasodilator (5). RAS and angiotensin II also play a role in interstitial fibrosis, cardiac remodeling and fibrosis, and heart failure (6, 7). It has also been shown that RAS operates in the heart, and the upregulation of this system is related to heart failure (8-10). Inhibition of ACE in patients with heart failure has often resulted in a favorable outcome for the patient (11). In this regard, captopril (2-D-methyl-3-mercaptopropanoyl-L-proline) was developed as an orally active ACE inhibitor and is considered an important drug for the treatment of hypertension. Subsequently, [18F]fluorocaptopril ([18F]FCAP) was developed for use with PET (12) to understand the in vivo dynamics of ACE activity.

Methyldopa

Because of the low levels of methyldopa in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants. No special precautions are required.

Captopril

Because of the low levels of captopril in breastmilk, amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.

Methyl 3,4-O-isopropyl-idene-2-O-[(methyl-sulfan-yl)thio-carbon-yl]-β-l-arabinoside

In the title compound, C(11)H(18)O(5)S(2), the six- and five-membered rings adopt a chair and an approximately planar conformation, respectively.

Mild Copper-Catalyzed, l-Proline-Promoted Cross-Coupling of Methyl 3-Amino-1-benzothiophene-2-carboxylate

Cu-catalyzed N-arylation is a useful tool for the chemical modification of aromatic heterocycles. Herein, an efficient carbon-nitrogen cross-coupling of methyl 3-amino-1-benzothiophene-2-carboxylate with a range of (hetero)aryl iodides using CuI, l-proline and Cs2CO3 in dioxane at moderate temperature is described. The procedure is an extremely general, relatively cheap, and experimentally simple way to afford the N-substituted products in moderate to high yields. The structures of the new heterocyclic compounds were confirmed by NMR spectroscopy and HRMS investigation.