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GSK2838232 Sale

目录号 : GC12329

An HIV maturation inhibitor

GSK2838232 Chemical Structure

Cas No.:1443461-21-9

规格 价格 库存 购买数量
5mg
¥1,491.00
现货
25mg
¥5,009.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

GSK2838232 is an HIV-1 maturation inhibitor [1] [2].

HIV-1 maturation inhibitors disrupt the cleavage of the HIV-1 gag protein immediate precursor by the enzyme HIV-1 protease. Maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. Also, maturation inhibitors inhibit HIV infections with resistance.

GSK2838232 is a HIV-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. GSK2838232 was developed for the treatment of chronic HIV infection. A phase I study in HIV-negative individuals had been completed. Single doses of 5, 10 or 20 mg GSK2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on GSK2838232’s bioavailability and pharmacokinetics [2].

References:
[1].  Olender SA, Taylor BS, Wong M, et al. CROI 2015: Advances in Antiretroviral Therapy. CROI 2015 Highlights: Antiretroviral Therapy Volume 23 Issue 1 March/April 2015.
[2].  Horn T, Collins S. The Antiretroviral Pipeline. Antiretrovirals, 2014 PIPELINE REPORT.

Chemical Properties

Cas No. 1443461-21-9 SDF
Canonical SMILES CC(C(C(C[C@@]([C@](O)([H])CN(CC1=CC=C(Cl)C=C1)CCN(C)C)2CC[C@]34C)=O)=C2[C@@]3([H])CC[C@]5([H])[C@]6(CC[C@@](OC(CC(C)(C(O)=O)C)=O)([H])C(C)(C6([H])CC[C@]54C)C)C)C
分子式 C48H73ClN2O6 分子量 809.56
溶解度 DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.2352 mL 6.1762 mL 12.3524 mL
5 mM 0.247 mL 1.2352 mL 2.4705 mL
10 mM 0.1235 mL 0.6176 mL 1.2352 mL
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