Home>>JWH 250 N-(4-hydroxypentyl) metabolite-d5

JWH 250 N-(4-hydroxypentyl) metabolite-d5 Sale

目录号 : GC47514

A neuropeptide with diverse biological activities

JWH 250 N-(4-hydroxypentyl) metabolite-d5 Chemical Structure

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100 μg
¥1,627.00
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500 μg
¥5,019.00
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1 mg
¥6,819.00
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Sample solution is provided at 25 µL, 10mM.

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产品描述

JWH 250 N-(4-hydroxypentyl) metabolite-d5 contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 250 N-(4-hydroxypentyl) metabolite by GC- or LC-mass spectrometry. JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB1 and CB2 receptors (Ki = 11 and 33 nM, respectively).1 It has been identified in herbal blends.2 JWH 250 N-(4-hydroxypentyl) metabolite is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.3,4,5

1.Huffman, J.W., Szklennik, P.V., Almond, A., et al.1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indolesBioorg. Med. Chem. Lett.15(18)4110-4113(2005) 2.Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y.Survey of current trends in the abuse of psychotropic substances and plants in JapanLeg. Med. (Tokyo)13(3)109-115(2011) 3.Wintermeyer, A., MÖller, I., Thevis, M., et al.In vitro phase I metabolism of the synthetic cannabimimetic JWH-018Anal. Bioanal. Chem.398(5)2141-2153(2010) 4.Zhang, Q., Ma, P., Cole, R.B., et al.Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MSAnalytical and Bioanalytical Chemistry3861345-1355(2006) 5.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES CC(O)CCCN1C2=C([2H])C([2H])=C([2H])C([2H])=C2C(C(CC3=C(OC)C=CC=C3)=O)=C1[2H]
分子式 C22H20D5NO3 分子量 356.5
溶解度 DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 14 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.805 mL 14.0252 mL 28.0505 mL
5 mM 0.561 mL 2.805 mL 5.6101 mL
10 mM 0.2805 mL 1.4025 mL 2.805 mL
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