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Irsogladine Sale

(Synonyms: 伊索拉定; Dicloguamine) 目录号 : GC13191

A gastroprotective agent

Irsogladine Chemical Structure

Cas No.:57381-26-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥389.00
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50mg
¥483.00
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产品描述

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.Target: PDE4; mACHRIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of the PKA pathway. It also suggests a useful adjuvant of Irsogladine to pancreatic cancer therapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

References:
[1]. Ren, C.J., et al., Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res, 1998. 77(2): p. 126-31.
[2]. Kawasaki, Y., et al., Irsogladine malate up-regulates gap junctional intercellular communication between pancreatic cancer cells via PKA pathway. Pancreas, 2002. 25(4): p. 373-7.
[3]. Kyoi, T., et al., Phosphodiesterase inhibition by a gastroprotective agent irsogladine: preferential blockade of cAMP hydrolysis. Life Sci, 2004. 75(15): p. 1833-42.

Chemical Properties

Cas No. 57381-26-7 SDF
别名 伊索拉定; Dicloguamine
化学名 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine
Canonical SMILES C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl
分子式 C9H7Cl2N5 分子量 256.09
溶解度 ≥ 12.8mg/mL in DMSO 储存条件 Store at -20°C
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1 mM 3.9049 mL 19.5244 mL 39.0488 mL
5 mM 0.781 mL 3.9049 mL 7.8098 mL
10 mM 0.3905 mL 1.9524 mL 3.9049 mL
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