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Maprotiline-d3 (hydrochloride) Sale

(Synonyms: Ba 34276-d3) 目录号 : GC48760

An internal standard for the quantification of maprotiline

Maprotiline-d3 (hydrochloride) Chemical Structure

Cas No.:1329496-63-0

规格 价格 库存 购买数量
500µg
¥982.00
现货
1mg
¥1,863.00
现货
5mg
¥8,343.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant.1,2 It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively).2 Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively).3 In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues.4 It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

1.Spencer, P.S.Review of the pharmacology of existing antidepressantsBr. J. Clin. Pharmacol.4(Suppl 2)57S-68S(1977) 2.Tatsumi, M., Groshan, K., Blakely, R.D., et al.Pharmacological profile of antidepressants and related compounds at human monoamine transportersEur. J. Pharmacol.340(2-3)249-258(1997) 3.Richelson, E., and Nelson, A.Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitroJ. Pharmacol. Exp. Ther.230(1)94-102(1984) 4.Pinder, R.M., Brogden, R.N., Speight, T.M., et al.Maprotiline: A review of its pharmacological properties and therapeutic efficacy in mental depressive statesDrugs13(5)321-352(1977)

Chemical Properties

Cas No. 1329496-63-0 SDF
别名 Ba 34276-d3
Canonical SMILES [2H]C([2H])([2H])NCCCC1(CC2)C3=CC=CC=C3C2C4=C1C=CC=C4.Cl
分子式 C20H20D3N•HCl 分子量 316.9
溶解度 DMSO: soluble,Methanol: soluble 储存条件 -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1556 mL 15.7778 mL 31.5557 mL
5 mM 0.6311 mL 3.1556 mL 6.3111 mL
10 mM 0.3156 mL 1.5778 mL 3.1556 mL
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