Home>>Signaling Pathways>> Immunology/Inflammation>>IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]

IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]

目录号 GP10044

IgG light chain region

规格 价格 库存 购买数量

Customer Review

Based on customer reviews.

电话:400-920-5774 Email: sales@glpbio.cn

Sample solution is provided at 25 µL, 10mM.


Quality Control & SDS

View current batch:


IgG has four forms, provides the majority of antibody-based immunity against invading pathogens.[1] The only antibody capable of crossing the placenta to give passive immunity to the fetus. IgM is expressed on the surface of B cells (monomer) and in a secreted form (pentamer) with very high avidity. Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG.[2] The immunoglobulin light chain is the small polypeptide subunit of an antibody ( immunoglobulin). Kappa (NJ) chain, one of the two types of light chain in mammals, is encoded by the immunoglobulin kappa locus (IGK@) on chromosome 2. Only V and J segments are found in Ig light chains.[3]

The approximate length of a light chain protein is from 211 to 217 amino acids.[4]

If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma.[5]

Increased levels of free Ig light chains have also been detected in various inflammatory diseases. Very recent studies have shown that Ig light chains not only activate mast cells but also dorsal root ganglia (Rijnierse, 2009)) and neutrophils (Braber and Thio (2012)), expanding their possible role as mediators in inflammatory disease.

1. Pier GB, Lyczak JB, Wetzler LM (2004). Immunology, Infection, and Immunity. ASM Press. ISBN 1-55581-246-5.
2. Geisberger R, Lamers M, Achatz G (2006). "The riddle of the dual expression of IgM and IgD". Immunology 118 (4): 060526021554006 -- . doi: 10.1111 / j. 1365-2567 . 2006.02386.x. PMC 1782314. PMID 16895553
3. Nemazee D (2006). "Receptor editing in lymphocyte development and central tolerance". Nat Rev Immunol 6 (10): 728-740. doi:10.1038/nri1939.PMID 16998507
4. Janeway CA, Jr. et al. (2001). Immunobiology. (5th ed.). Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X.
5. Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd.. pp. 283-285.ISBN 1-84110-100-1.

Chemical Properties

Cas No. N/A SDF
别名 H2N-Thr-Asp-Phe-Thr-Leu-Thr-Ile-OH
化学名 N/A
Canonical SMILES C[C@@H](O)[C@H](N)C(NC(CC(O)=O)C(NC(CC1=CC=CC=C1)C(N[C@@H]([C@@H](O)C)C(NC(CC(C)C)C(N[C@H](C(N[C@H]([C@@H](C)CC)C(O)=O)=O)[C@@H](O)C)=O)=O)=O)=O)=O
分子式 C37H59N7O13 分子量 809.9
溶解度 ≥ 81mg/mL in DMSO 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

动物体内配方计算器 (澄清溶液)

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
% DMSO % % Tween 80 % ddH2O
  • 摩尔浓度计算器

  • 稀释计算器

*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。