IDS Human
目录号 : GP21825Iduronate 2-Sulfatase Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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IDS Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 533 amino acids (26-550a.a) and having a molecular mass of 60.3kDa. (Molecular size on SDS-PAGE will appear at approximately 35-70kDa). IDS is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
| Purity | Greater than 90% as determined by SDS-PAGE. | Source | Sf9,Baculovirus cells. |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | Iduronate 2-Sulfatase; Alpha-L-Iduronate Sulfate Sulfatase; SIDS; Iduronate 2-Sulfatase 14 KDa Chain; Iduronate 2-Sulfatase 42 KDa Chain; Hunter Syndrome; EC 3.1.6.13; MPS2; Iduronate 2-sulfatase; Alpha-L-iduronate sulfate sulfatase. | ||
| Amino Acid Sequence | SETQANSTTD ALNVLLIIVD DLRPSLGCYG DKLVRSPNID QLASHSLLFQNAFAQQAVCA PSRVSFLTGR RPDTTRLYDF NSYWRVHAGN FSTIPQYFKE NGYVTMSVGK VFHPGISSNHTDDSPYSWSF PPYHPSSEKY ENTKTCRGPD GELHANLLCP VDVLDVPEGT LPDKQSTEQAIQLLEKMKTS ASPFFLAVGY HKPHIPFRYP KEFQKLYPLE NITLAPDPEVPDGLPPVAYN PWMDIRQRED VQALNISVPY GPIPVDFQRK IRQSYFASVS YLDTQVGRLL SALDDLQLANSTIIAFTSDH GWALGEHGEW AKYSNFDVAT HVPLIFYVPG RTASLPEAGE KLFPYLDPFDSASQLMEPGR QSMDLVELVS LFPTLAGLAG LQVPPRCPVP SFHVELCREGKNLLKHFRFR DLEEDPYLPG NPRELIAYSQ YPRPSDIPQW NSDKPSLKDI KIMGYSIRTI DYRYTVWVGFNPDEFLANFS DIHAGELYFV DSDPLQDHNM YNDSQGGDLF QLLMPLEHHH HHH. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | IDS protein solution (0.25mg/ml) containing PhosphateBuffered Saline (pH 7.4) and 10% glycerol. | ||
Iduronate 2-Sulfatase also known as IDS,belongs to the highly-conserved sulfatase family of enzymes which catalyze thehydrolysis of O-sulfate and N-salfate esters from a variety of substrates. IDS isessential for the lysosomal degradation of the glycosaminoglycans (GAG) heparansulfate as well as dermatan sulfate. Furthermore, IDS hydrolyzes the 2-sulfategroup of the IDS units of the GAG.
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.