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heparin cofactor II precursor fragment [Homo sapiens] Sale

(Synonyms: H2N-Tyr-Glu-Ile-Thr-Thr-Ile-His-Asn-Leu-Phe-Arg-OH ) 目录号 : GP10027

Thrombin inhibitor

heparin cofactor II precursor fragment [Homo sapiens] Chemical Structure

规格 价格 库存 购买数量
1mg
¥378.00
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5mg
¥1,134.00
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10mg
¥1,796.00
现货
25mg
¥2,594.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

heparin cofactor II precursor fragment [Homo sapiens], (C65H99N17O18), a peptide with the sequence H2N-Tyr-Glu-Ile-Thr-Thr-Ile-His-Asn-Leu-Phe-Arg-OH, MW=1406.58. Heparin cofactor II(HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan sulfate1. The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency2. Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state.

References:
1. Pizzo SV (1989). "Serpin receptor 1: a hepatic receptor that mediates the clearance of antithrombin III-proteinase complexes.". Am. J. Med. 87 (3B): 10S-14S.
2. Sutherland JS, Bhakta V, Filion ML, SheffieldWP (2006). "The transferable tail: fusion of the N-terminal acidic extension of heparin cofactor II to alpha1-proteinase inhibitor M358R specifically increases the rate of thrombin inhibition.". Biochemistry 45 (38): 11444-52.

Chemical Properties

Cas No. SDF
别名 H2N-Tyr-Glu-Ile-Thr-Thr-Ile-His-Asn-Leu-Phe-Arg-OH
分子式 C65H99N17O18 分子量 1406.58
溶解度 ≥ 140.7mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.7109 mL 3.5547 mL 7.1094 mL
5 mM 0.1422 mL 0.7109 mL 1.4219 mL
10 mM 0.0711 mL 0.3555 mL 0.7109 mL
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