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Furprofen Sale

目录号 : GC38379

Furprofen 是一种非甾体类抗炎药 (NSAID)。Furprofen 通过抑制前列腺素 (PGE) 合成发挥作用。Furprofen 口服可以减轻疼痛。

Furprofen Chemical Structure

Cas No.:66318-17-0

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10mM (in 1mL DMSO)
¥3,465.00
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5mg
¥3,150.00
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10mg
¥4,950.00
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50mg
¥14,850.00
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100mg
¥20,250.00
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产品描述

Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties[1]. Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain[2][3].

[1]. Carlucci G, et al. A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma. Biomed Chromatogr. 1993 May-Jun;7(3):126-8. [2]. Locatelli M, et al. Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine. J Chromatogr A. 2014 Nov 7;1367:1-8.

Chemical Properties

Cas No. 66318-17-0 SDF
Canonical SMILES O=C(C1=CC=CO1)C2=CC=C(C(C)C(O)=O)C=C2
分子式 C14H12O4 分子量 244.24
溶解度 Ethanol: 100 mg/mL (409.43 mM); DMSO: 62.5 mg/mL (255.90 mM) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mM 4.0943 mL 20.4717 mL 40.9433 mL
5 mM 0.8189 mL 4.0943 mL 8.1887 mL
10 mM 0.4094 mL 2.0472 mL 4.0943 mL
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Research Update

Fast off-line FPSE-HPLC-PDA determination of six NSAIDs in saliva samples

J Chromatogr B Analyt Technol Biomed Life Sci 2020 May 1;1144:122082.PMID:32278291DOI:10.1016/j.jchromb.2020.122082.

A fast off-line FPSE-HPLC-PDA method has been reported that allows simultaneous clean up and determination of six non-steroidal anti-inflammatory drugs (NSAIDs) in saliva samples from healthy volunteers. Particularly, Furprofen, indoprofen, ketoprofen, fenbufen, flurbiprofen, and ibuprofen were chromatographically resolved. Benzyl paraben was chosen as the internal standard (BzPB, IS). These target compounds were successfully extracted from human saliva using fabric phase sorptive extraction (FPSE) and then analysed in the liquid chromatographic system by means of a short analytical column (Symmetry C18, 75 × 4.6 mm, 3.5 µm) using acetonitrile (AcN) and phosphate buffer (PBS, 30 mM; pH = 2.5) as the mobile phases. The method, validated through the calculation of all analytical parameters in accordance of International Guidelines, was applied to real saliva sample analysis collected from informed volunteers. The proposed approach that included the use of sol-gel polytetrahydrofuran (sol-gel PTHF) sorbent immobilized on cellulose support and C18 stationary phase used in HPLC, showed high potential as a fast tool for future clinical and forensic applications. The herein reported results encourage potential future application of FPSE in the forensic field. Furthermore, the FPSE membrane was tested in dried saliva spot mode (DSS) in order to check its potential use as a sampling device, also for forensic applications.

A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and Furprofen in rat plasma

Biomed Chromatogr 1993 May-Jun;7(3):126-8.PMID:8318826DOI:10.1002/bmc.1130070303.

A rapid and simple high performance liquid chromatographic analytical method is described for the simultaneous determination of norfloxacin and Furprofen in rat plasma. Following dichloromethane extraction, the solution was chromatographed in a Vydac anion exchange column using a mobile phase of 0.05 M phosphate buffer (pH = 7.0): acetonitrile (80:20, v/v) at a flow-rate of 1.8 mL/min. The drugs were detected by UV absorption at 278 nm. The total chromatographic analysis time was 10 min. The response was linear, 0.1-5.0 micrograms/mL for norfloxacin and 0.1-3.0 micrograms/mL for Furprofen, respectively. This method is useful for pharmacokinetic studies of these compounds and will facilitate detailed investigations into the interactions between quinolones and Furprofen.

Simultaneous determination of Furprofen and rufloxacin in human plasma by high-performance liquid chromatography

J Chromatogr Sci 1996 Apr;34(4):182-4.PMID:8901133DOI:10.1093/chromsci/34.4.182.

A simple and reproducible method for the simultaneous determination of the nonsteroidal anti-inflammatory agent, Furprofen, and the quinolone antimicrobial agent, rufloxacin, in human plasma is described. It involves a two-step liquid-liquid extraction and a separation using an LC-SAX column with ultraviolet detection at 280 nm. Fenbufen is used as the internal standard. Within-day and between-day coefficients of variation are less than 6%. The lower limits of detection are 0.05 and 0.03 micrograms/mL for Furprofen and rufloxacin, respectively. The method is suitable for pharmacological, toxicological, and pharmacokinetic studies of Furprofen and rufloxacin.

Simultaneous determination of rufloxacin and Furprofen in plasma by derivative UV-spectrophotometry

Farmaco 1994 Jul-Aug;49(7-8):527-8.PMID:7945721doi

A procedure for the simultaneous determination of rufloxacin and Furprofen in rat plasma by second-derivative UV-spectrophotometry is described. The proposed method, which gives useful data for pharmacokinetic studies, is simple and rapid, and allows precise and accurate results.

Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine

J Chromatogr A 2014 Nov 7;1367:1-8.PMID:25278162DOI:10.1016/j.chroma.2014.09.034.

This paper reports a new MEPS-HPLC-PDA method for the simultaneous analysis of seven non-steroidal anti-inflammatory drugs (Furprofen, Indoprofen, Ketoprofen, Fenbufen, Flurbiprofen, Indomethacin, and Ibuprofen) in human plasma and urine. NSAIDs were resolved on a Gemini C18 column (4.6 mm × 250 mm; 5 μm particle size) using a gradient elution mode with a run time of 25 min, comprising re-equilibration, without further purification. The method was validated over the concentration range from 0.1 to 10 μg/mL for all the analytes both in human plasma and urine, using Benzyl 4-hydroxybenzoate as the internal standards. This method was successfully tested to NSAIDs analyses in real matrices, in order to check the method potentiality and the correct response. The results from assay validations show that the method is selective, sensitive and robust. The limit of quantification of the method was 0.1 μg/mL for all analytes, and weighted-matrix-matched standard curves showed a good linearity up to 10 μg/mL. In order to check the correct response for over-range samples, parallelism tests were also assessed. In the entire analytical range the intra and inter-day precision (RSD%) values were ≤ 7.31% and ≤ 13.5%, respectively. For all the analytes the intra and inter-day trueness (Bias%) values ranged from -11.3% to 10.2%. To our knowledge, this is the first MEPS-HPLC-PDA based method that uses MEPS procedure for simultaneous determination of these seven NSAIDs in plasma and urine samples.