Lucideric acid A
(Synonyms: 赤芝酸 A) 目录号 : GC36491
A triterpene with anticancer activity
Cas No.:95311-94-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Lucidenic acid A is a triterpene originally isolated from G. lucidum and has anticancer activity.1,2 It is cytotoxic to HepG2, HepG2 2.2.15', and P388 cancer cells (IC50s = 0.164, 0.205, and 17 nM, respectively). Lucidenic acid A inhibits increases in matrix metalloproteinase-2 (MMP-2) and MMP-9 activity and Matrigel? invasion induced by phorbol 12-myristate 13-acetate in HepG2 cells.2
1.Wu, T.-S., Shi, L.-S., and Kuo, S.-C.Cytotoxicity of Ganoderma lucidum triterpenesJ. Nat. Prod.64(8)1121-1122(2001) 2.Weng, C.-J., Chau, C.-F., Chen, K.-D., et al.The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strainMol. Nutr. Food Res.51(12)1472-1477(2007)
| Cas No. | 95311-94-7 | SDF | |
| 别名 | 赤芝酸 A | ||
| Canonical SMILES | C[C@]12C3=C(C(C[C@@]1([C@]([C@H](C)CCC(O)=O)([H])CC2=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C | ||
| 分子式 | C27H38O6 | 分子量 | 458.59 |
| 溶解度 | Acetonitrile: soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.1806 mL | 10.903 mL | 21.806 mL |
| 5 mM | 0.4361 mL | 2.1806 mL | 4.3612 mL |
| 10 mM | 0.2181 mL | 1.0903 mL | 2.1806 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Determination of nine triterpenoid acids from Ganoderma lucidum of different producting areas by HPLC]
Zhongguo Zhong Yao Za Zhi 2012 Dec;37(23):3599-603.PMID:23477148doi
Objective: To establish an HPLC method for determining nine triterpenes contained in Ganoderma lucidum. Method: Chromatography conditions: Alltima C18 (4.6 mm x 150 mm, 5 microm) was adopted as the chromatographic column, with acetonitrile-0.04% formic acid solution as the mobile phase. The detective wavelength was set at 254 nm, and the column temperature was 15 degrees C. Result: The linearities of ganoderic acid C2, ganoderic acid G, ganoderenic acid B, ganoderic acid B, ganoderenic acid A, ganoderic acid A, Lucideric acid A, ganoderenic acid D, and ganoderic acid C1 ranged between 6.81-40.88, 6.38-38.25, 6.75-40.50, 6.38-38.25, 5.95-35.65, 5.90-35.25, 7.00-42.00, 6.20-37.15 and 6.05-36.4 mg x L(-1) (r = 0.999 4, 0.999 2, 0.999 4, 0.999 2, 0.999 2, 0.994 5, 0.999 0, 0.999 2 and 0.998 4). Their recoveries were 102.1%, 102.3%, 100.6%, 103.3%, 104.1%, 103.2%, 96.42%, 102.5% and 101.5%, with RSD being 1.5%, 0.96%, 1.9%, 1.3%, 1.7%, 2.5%, 0.62%, 2.9% and 1.3%. The content of triterpenes contained in G. lucidum samples from 31 different areas and under different cultivation conditions. Conclusion: The method is so feasible and highly reproducible that it can be used for quantitatie determination of the content of triterpenoid acid contained in G. lucidum.