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PF-06873600 目录号 GC32832

规格 价格 库存 购买数量
10mM*1mLinDMSO
¥5,399.00
现货
5mg
¥4,909.00
现货
10mg
¥7,586.00
现货
25mg
¥15,619.00
现货
50mg
¥24,544.00
现货
100mg
¥35,254.00
现货

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 2185857-97-8 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES O=S(N1CCC(NC2=NC3=C(C=C(C(F)F)C(N3[C@@H]4CCC[C@]4(O)C)=O)C=N2)CC1)(C)=O
分子式 C20H27F2N5O4S 分子量 471.52
溶解度 DMSO : 83.33 mg/mL (176.73 mM; Need ultrasonic) 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

PF-06873600 is a selective and orally bioavailable inhibitor of cyclin-dependent kinase (CDK), with Ki values of 0.09 nM, 0.13 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. PF-06873600 has potential antineoplastic activity[1][2].

PF-06873600 (Example 8) is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity[1]. PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells[2].

[1]. US 2018/0044344 A1. [2]. NCI Drug Dictionary