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FKGK 18 Sale

目录号 : GC43671

An inhibitor of GVIA iPLA2

FKGK 18 Chemical Structure

Cas No.:1071001-09-6

规格 价格 库存 购买数量
5mg
¥1,696.00
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10mg
¥3,221.00
现货
25mg
¥7,213.00
现货
50mg
¥11,872.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8% inhibition, respectively. FKGK 18 inhibits iPLA2β activity in cytosolic extracts from INS-1 cells overexpressing iPLA2β (IC50 = ~50 nM) as well as iPLA2γ activity in mouse heart membrane fractions (IC50s = ~1-3 μM). It inhibits glucose-induced increases in prostaglandin E2 production and insulin secretion in human pancreatic islets when used at a concentration of 10 μM and inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2β in a concentration-dependent manner. FKGK 18 (20 mg/kg, 3 times per week) reduces blood glucose levels in an intraperitoneal glucose tolerance test, decreases the incidence of diabetes, and increases serum insulin levels in non-obese diabetic (NOD) mice.

Chemical Properties

Cas No. 1071001-09-6 SDF
Canonical SMILES O=C(C(F)(F)F)CCCCC1=CC2=CC=CC=C2C=C1
分子式 C16H15F3O 分子量 280.3
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,PBS (pH 7.2): 2 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.5676 mL 17.838 mL 35.6761 mL
5 mM 0.7135 mL 3.5676 mL 7.1352 mL
10 mM 0.3568 mL 1.7838 mL 3.5676 mL
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