FGF4 Human
目录号 : GP20220Fibroblast Growth Factor-4 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. | Shipping Condition | Shipped at Room temp. |
| Synonyms | HBGF4; FGF-4; FGF4; KFGF; HSTF1. | ||
| Amino Acid Sequence | GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL. | ||
| Solubility | It is recommended to reconstitute the lyophilized FGF4 Human Recombinant sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | ||
| Stability | Lyophilized FGF4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution FGF-4 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles. | ||
| Biological Activity | The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤0.5ng/ml, corresponding to a specific activity of ≥ 2,000,000units/mg. | ||
| Formulation | The FGF4 protein was lyophilized with 2xPBS, pH 7.4. | ||
FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤0.5ng/ml, corresponding to a specific activity of ≥ 2,000,000units/mg.
Lyophilized FGF4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution FGF-4 should be stored at 4°C between 2-7 days and for future use below -18°C .Please prevent freeze-thaw cycles.