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Famciclovir Sale

(Synonyms: 泛昔洛韦; BRL 42810) 目录号 : GC17947

An orally bioavailable prodrug form of penciclovir

Famciclovir Chemical Structure

Cas No.:104227-87-4

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥368.00
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50mg
¥431.00
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100mg
¥725.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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产品描述

Famciclovir is an oral prodrug of penciclovir [1].

Famciclovir is an oral prodrug of anti- herpesvirus drug penciclovir since penciclovir is poorly absorbed when given orally to rodents. Famciclovir is a diester derivative of 6-deoxy-penciclovir. It can be quickly absorbed and converted to the antiviral drug efficiently both in rat tissues and fluids and in human tissues and fluids. Besides that, famciclovir is relatively stable in the duodenal contents and can give consistent levels of penciclovir in blood. Currently, famciclovir is approved to be used for the treatment of herpes zoster, herpes labialis, genital herpes in immunocompetent adult patients and HSV in immunocompromised adults [1, 2].

References:
[1] Hodge R A V, Sutton D, Boyd M R, et al. Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl) guanine; penciclovir]. Antimicrobial agents and chemotherapy, 1989, 33(10): 1765-1773.
[2] Sáez-Llorens X, Yogev R, Arguedas A, et al. Pharmacokinetics and safety of famciclovir in children with herpes simplex or varicella-zoster virus infection. Antimicrobial agents and chemotherapy, 2009, 53(5): 1912-1920.

Chemical Properties

Cas No. 104227-87-4 SDF
别名 泛昔洛韦; BRL 42810
化学名 [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
Canonical SMILES CC(=O)OCC(CCN1C=NC2=CN=C(N=C21)N)COC(=O)C
分子式 C14H19N5O4 分子量 321.33
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 10 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.1121 mL 15.5603 mL 31.1207 mL
5 mM 0.6224 mL 3.1121 mL 6.2241 mL
10 mM 0.3112 mL 1.556 mL 3.1121 mL
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