Ecamsule disodium
(Synonyms: 依茨舒二钠) 目录号 : GC61828
Ecamsule disodium是一种水溶性的广谱长波紫外线（UVA）吸收剂，覆盖300–400nm的UVA波段，最大吸收峰位于344nm。
Cas No.:90458-75-6
Sample solution is provided at 25 µL, 10mM.
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Ecamsule disodium is a water-soluble broad-spectrum long-wave ultraviolet light (UVA)-absorber covering a wide range of UVA radiation from 300 to 400nm, with maximum absorbance at 344nm. Ecamsule disodium exhibited significant protection against UV induced and chemical oxidative stress (AAPH)-induced ROS levels[1][2]. Ecamsule disodium provides clinical benefit to patients with polymorphous light eruption (PMLE)[3].
In vitro, Ecamsule disodium (200-1600μM) was applied to human keratinocyte (HaCaT) and fibroblast (WT Fibs E6/E7) cell lines for 1h before exposure to UV radiation. Ecamsule disodium significantly reduced UV-induced ROS levels in fibroblasts and keratinocytes by up to 25.7% and 14.5% respectively at 1600μM[1]. Ecamsule disodium (50, 500, and 5000ng/L) was applied on digestive glands and gills tissues of Mytilus galloprovincialis mussle for 30min. Ecamsule disodium has a relatively low toxicological impact comparing to other UV filters such as Ethylhexylmethoxycinnamate (EHMC) and Octocrylene (OC). Ecamsule disodium did not induce oxidative stress or cellular damage and only slightly enhanced biotransformation enzyme activity (CbEs) in digestive glands[2].
References:
[1] Hofer S, Stonig M, Wally V, et al. Contradictory effects of chemical filters in UV/ROS-stressed human keratinocyte and fibroblast cells. ALTEX. 2019;36(2):231-244.
[2] Bordalo D, Soares A M V M, Sokolova I, Pretti C, Freitas R. Hidden costs of beauty: An in vitro study on the ecotoxicological impacts of ultraviolet filters and parabens on the bioindicator species Mytilus galloprovincialis. Mar Pollut Bull. 2025 Nov:220:118403.
[3] DeLeo V A, Clark S, Fowler J, et al. A new ecamsule-containing SPF 40 sunscreen cream for the prevention of polymorphous light eruption: a double-blind, randomized, controlled study in maximized outdoor conditions. Cutis. 2009 Feb;83(2):95-103.
Ecamsule disodium是一种水溶性的广谱长波紫外线（UVA）吸收剂，覆盖300–400nm的UVA波段，最大吸收峰位于344nm。Ecamsule disodium在UV诱导及化学氧化应激（AAPH）条件下均显著抑制ROS生成[1][2]，并对多形性日光疹（PMLE）患者具有临床益处[3]。
体外实验中，Ecamsule disodium（200–1600μM）提前作用于人角质形成细胞（HaCaT）和成纤维细胞（WT Fibs E6/E7）1h，再接受UV刺激，在1600μM时，Ecamsule disodium分别使成纤维细胞和角质细胞的UV诱导ROS水平降低25.7%和14.5%[1]。Ecamsule disodium（50、500、5000ng/L）处理Mytilus galloprovincialis贻贝消化腺和鳃组织30min，与Ethylhexylmethoxycinnamate（EHMC）和Octocrylene（OC）等UV滤光剂相比，Ecamsule disodium毒性较低，未引起氧化应激或细胞损伤，并且仅在消化腺中轻微增强了生物转化酶活性（CbEs）[2]。
| Cell experiment [1]: | |
Cell lines | Human keratinocyte HaCaT and the wildtype Fibs E6/E7 fibroblast cell lines |
Preparation Method | The cells were treated with increasing concentrations of Ecamsule disodium ranging from 200 to 1600µM for 1h before exposure to UV radiation. |
Reaction Conditions | 200-1600μΜ; 1h |
Applications | Ecamsule disodium significantly reduced UV-induced ROS levels in fibroblasts and keratinocytes by up to 25.7% and 14.5% respectively at 1600μM. |
References: | |
| Cas No. | 90458-75-6 | SDF | |
| 别名 | 依茨舒二钠 | ||
| Canonical SMILES | O=[S](CC(C1=O)(CCC2/C1=C/C(C=C3)=CC=C3/C=C(C4=O)/C(CCC45C[S](=O)(O[Na])=O)C5(C)C)C2(C)C)(O[Na])=O | ||
| 分子式 | C28H32Na2O8S2 | 分子量 | 606.66 |
| 溶解度 | DMSO : 50 mg/mL (82.42 mM) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6484 mL | 8.2418 mL | 16.4837 mL |
| 5 mM | 329.7 μL | 1.6484 mL | 3.2967 mL |
| 10 mM | 164.8 μL | 824.2 μL | 1.6484 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet