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DCXR Human, Bioactive

目录号 : GP21547

Dicarbonyl/L-Xylulose Reductase Human Recombinant, Bioactive

DCXR Human, Bioactive Chemical Structure

规格 价格 库存 购买数量
2μg
¥840.00
5-10工作日
10μg
¥2,030.00
5-10工作日
1mg
¥72,800.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

DCXR Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 264 amino acids (1-244 a.a.) and having a molecular mass of 28 kDa. The DCXR is fused to a 20 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Product Data

Purity Greater than 95.0% as determined by SDS-PAGE. Source Escherichia Coli.
Phycical Appearance Sterile filtered colorless solution. Shipping Condition Shipped with Ice Packs.
Synonyms DCR; HCR2; HCRII; KIDCR; P34H; SDR20C1; Dicarbonyl/L-Xylulose Reductase; EC=1.1.1.10; Carbonyl reductase II; Kidney dicarbonyl reductase; Sperm surface protein P34H.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC.
Stability Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Biological Activity Specific activity is > 1,800 pmol/min/ug and isdefined as the amount of enzyme that oxidize 1pmole of xylitol to L-xyluloseper minute at pH 10.0 at 37C.
Formulation The DCXR (0.5mg/ml) solution containing 20mM Tris-HClbuffer (pH 8.0), 1mM DTT, 20% glycerol and 50mM NaCl.

Introduction

DCXR catalyzes the NADPH-dependent reduction of numerous pentoses, tetroses, trioses, alpha-dicarbonyl molecules and L-xylulose. DCXR takes part in the uronate cycle of glucose metabolism. DCXR participates in the water absorption andcellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thus preventing osmolytic stress from occurring in the renal tubules.

Biological Activity

Specific activity is > 1,800 pmol/min/ug and isdefined as the amount of enzyme that oxidize 1pmole of xylitol to L-xyluloseper minute at pH 10.0 at 37C.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.