Cymoxanil-d3
(Synonyms: 霜脲氰 d3) 目录号 : GC47156
An internal standard for the quantification of cymoxanil
Cas No.:2140803-92-3
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Cymoxanil-d3 is intended for use as an internal standard for the quantification of cymoxanil by GC- or LC-MS. Cymoxanil is a cyanoacetamide fungicide.1,2 It inhibits the mycelial growth of 12 isolates of P. infestans with EC50 values of 0.27-0.57 μg/ml.3 Cymoxanil (5-100 mg/L) inhibits the growth of several strains of S. cerevisiae (IC50s = 8-25 mg/L) but not S. pombe, K. marxianus, P. anomala, or C. utilis.4 A spray application of cymoxanil (1 mg/ml) one day after inoculation of potato leaves with P. infestans and cucumber leaves with P. cubensis reduces blighted leaves by 79 and 60%, respectively.1 It is toxic to rats with an acute LD50 value of 3.8 mmol/kg.5 Formulations containing cymoxanil have been used to prevent fungal growth on crops and treat late potato blight in agriculture.
1.Cohen, Y., and Grinberger, M.Control of metalaxyl-resistant causal agents of late blight in potato and tomato and downy mildew in cucumber by cymoxanilPhytopathology77(9)1283-1288(1987) 2.Baude, F.J., and Cupery, W.E.2-Alkoxyimino-N-carbamoyl-2-cyanoacetamide-containing fungicide compositions(1975) 3.Rekanovi?, E., Poto?nik, I., Milijaševi?-Mar?i?, S., et al.Toxicity of metalaxyl, azoxystrobin, dimethomorph, cymoxanil, zoxamide and mancozeb to Phytophthora infestans isolates from SerbiaJ. Environ. Sci. Health B.47(5)403-409(2012) 4.Ribeiro, I.C., VerÍssimo, I., Moniz, L., et al.Yeasts as a model for assessing the toxicity of the fungicides Penconazol, Cymoxanil and DichlofluanidChemosphere41(10)1637-1642(2000) 5.Hamadache, M., Benkortbi, O., Hanini, S., et al.A quantitative structure activity relationship for acute oral toxicity of pesticides on rats: Validation, domain of application and predictionJ. Hazard. Mater.30328-40(2016)
| Cas No. | 2140803-92-3 | SDF | |
| 别名 | 霜脲氰 d3 | ||
| Canonical SMILES | CCNC(NC(/C(C#N)=N/OC([2H])([2H])[2H])=O)=O | ||
| 分子式 | C7H7D3N4O3 | 分子量 | 201.2 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly soluble | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.9702 mL | 24.8509 mL | 49.7018 mL |
| 5 mM | 0.994 mL | 4.9702 mL | 9.9404 mL |
| 10 mM | 0.497 mL | 2.4851 mL | 4.9702 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。