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C18 Ceramide-d7 (d18:1-d7/18:0)

(Synonyms: C18 Ceramide-d7) 目录号 : GC46988

An internal standard for the quantification of C18 ceramide

C18 Ceramide-d7 (d18:1-d7/18:0) Chemical Structure

Cas No.:1840942-14-4

规格 价格 库存 购买数量
500 μg
¥5,122.00
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1 mg
¥9,217.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

C18 Ceramide-d7 is intended for use as an internal standard for the quantification of C18 ceramide by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.[1] Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.[2] It is selectively down-regulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.[3]

Reference:
[1].Mizutani, Y., Kihara, A., and Igarashi, Y.Mammalian Lass6 and its related family members regulate synthesis of specific ceramidesBiochem J.390(Pt. 1)263-271(2005)
[2].Koybasi, S., Senkal, C.E., Sundararaj, K., et al.Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomasJ. Biol. Chem.279(43)44311-44319(2004)
[3].Bergman, B.C., Brozinick, J.T., Strauss, A., et al.Muscle sphingolipids during rest and exercise: A C18:0 signature for insulin resistance in humansDiabetologia59(3)785-791(2016)

Chemical Properties

Cas No. 1840942-14-4 SDF
别名 C18 Ceramide-d7
化学名 N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-15,15,16,16,17,17,17-d7]-octadecanamide
Canonical SMILES OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
分子式 C36H64D7NO3 分子量 573
溶解度 DMF: 0.15 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.7452 mL 8.726 mL 17.452 mL
5 mM 0.349 mL 1.7452 mL 3.4904 mL
10 mM 0.1745 mL 0.8726 mL 1.7452 mL
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