Benzedrone (hydrochloride)
(Synonyms: 4MBC) 目录号 : GC42916An Analytical Reference Standard
Cas No.:1797979-43-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4-Methylmethcathinone (also known as Mephedrone) is a stimulatory designer drug found in bath salts and similar products. Benzedrone is an analog of mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety. The physiological and toxicological properties of this compound are unknown. This product is intended for forensic and research applications.
| Cas No. | 1797979-43-1 | SDF | |
| 别名 | 4MBC | ||
| Canonical SMILES | CC1=CC=C(C(C(C)NCC2=CC=CC=C2)=O)C=C1.Cl | ||
| 分子式 | C17H19NO•HCl | 分子量 | 289.8 |
| 溶解度 | DMF: 10 mg/ml,DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 5 mg/ml,DMSO: 5 mg/ml,Ethanol: 5 mg/ml,Ethanol: 5 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.4507 mL | 17.2533 mL | 34.5066 mL |
| 5 mM | 0.6901 mL | 3.4507 mL | 6.9013 mL |
| 10 mM | 0.3451 mL | 1.7253 mL | 3.4507 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Ritalin, Benzedrine and Dexedrine do not transform F 1706 rat cells
Cancer Lett 1978 Dec;5(6):345-9.PMID:728890DOI:10.1016/s0304-3835(78)80061-5.
Ritalin (methylphenidate hydrochloride), Benzedrine (amphetamine sulfate), and Dexedrine (dextroamphetamine sulfate) were examined for oncogenicity using a serial line of Fischer rat embryo cells, which was previously shown to be a sensitive and accurate indicator of chemicals carcinogenic for rodents. At the concentrations tested, none of the 3 drugs induced transformation in Fischer rat embryo cells.
The use of psychostimulants in general psychiatry. A reconsideration
Arch Gen Psychiatry 1987 Mar;44(3):286-95.PMID:2881528DOI:10.1001/archpsyc.1987.01800150110013.
A half century after the introduction of amphetamine sulfate (benzedrine), there remains active interest in the use of the major psychostimulants (ie, methylphenidate hydrochloride and pemoline) for the treatment of psychiatric disorders. In the absence of any recent review of the literature on the clinical uses of psychostimulants, we assessed the existing data on the adult psychiatric indications for these agents. Generally, the existing studies are old and inadequate. However, there is some evidence to support the judicious use of psychostimulants in selected clinical instances of several adult psychiatric syndromes.
Sensitivity to subjective effects of cocaine in drug abusers: relationship to cerebral ventricle size
Am J Psychiatry 1993 Nov;150(11):1712-7.PMID:8214181DOI:10.1176/ajp.150.11.1712.
Objective: The purpose of this study was to assess the functional significance of ventricle-brain ratio (VBR) in terms of how it might affect sensitivity to cocaine, an indirect dopamine agonist. Method: Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism. Results: Subjective measures of effects of cocaine, including self-report ratings of intensity of the drug effect, scores on the morphine-benzedrine scale of the Addiction Research Center Inventory, and several items on visual analogue scales, correlated negatively with VBR. VBR also differed significantly among subjects who were grouped according to scores on items ("rush" and "crash") of the Cocaine-Sensitive Scale (larger VBR in subjects with weaker responses). VBR was not correlated with cocaine-induced changes in cerebral metabolic rates for glucose. Conclusions: Relative insensitivity to the subjective effects of cocaine in polydrug abusers with ventricle enlargement suggests that ventriculomegaly may reflect changes in periventricular brain regions that mediate these effects of cocaine.