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Irbesartan-d4 Sale

(Synonyms: 厄贝沙坦 D4; SR-47436-d4; BMS-186295-d4) 目录号 : GC40208

An internal standard for the quantification of irbesartan

Irbesartan-d4 Chemical Structure

Cas No.:1216883-23-6

规格 价格 库存 购买数量
500μg
¥1,879.00
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1mg
¥3,569.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan by GC- or LC-MS. Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM). It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II. Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet. It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin . Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.

Chemical Properties

Cas No. 1216883-23-6 SDF
别名 厄贝沙坦 D4; SR-47436-d4; BMS-186295-d4
Canonical SMILES CCCCC1=NC2(CCCC2)C(N1CC3=C([2H])C([2H])=C(C4=C(C5=NNN=N5)C=CC=C4)C([2H])=C3[2H])=O
分子式 C25H24D4N6O 分子量 432.6
溶解度 Methanol: Heated 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 2.3116 mL 11.558 mL 23.116 mL
5 mM 0.4623 mL 2.3116 mL 4.6232 mL
10 mM 0.2312 mL 1.1558 mL 2.3116 mL
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