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BAM 22P Sale

(Synonyms: Bovine adrenal medulla-22P) 目录号 : GC11390

A neuropeptide

BAM 22P Chemical Structure

Cas No.:76622-26-9

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1mg
¥2,268.00
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产品描述

IC50: 1.3 nM for opiate activity

Bovine adrenal medulla 22 peptide (BAM22P) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin A, the precursor of Leu- and Met-enkephalin, in the adrenal medulla, with very potent opiate activity.

In vitro: In the guinea-pig ileum assay, BAM-22P has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. The potency of BAM-22P is 26 times that of Met-enkephalin and 22 times that of B hendorphin. IC50 value of BAM-22P in this tissue, 1.3 nM, makes it the most potent Met-enkephalin relatives that discoveried so far. [1].

In vivo: Intrathecal (i.t.) administration of BAM22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. Such decrease was partially attenuated by systemic injection of naloxone. [2].

Clinical trial: Up to now, BAM 22P is still in the preclinical development stage.

Reference:
[1] Mizuno K, Minamino N, Kangawa K, Matsuo H.  A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem Biophys Res Commun. 1980 Dec 31;97(4):1283-90.
[2] Hong Y, Dai P, Jiang J, Zeng X.  Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. Br J Pharmacol. 2004 Feb;141(3):423-30.

Chemical Properties

Cas No. 76622-26-9 SDF
别名 Bovine adrenal medulla-22P
化学名 (3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,32S)-26,29-bis((1H-indol-3-yl)methyl)-32-((Z)-(((S)-1-((2S,3Z,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,24Z,27Z,29S)-29-amino-20-benzyl-2,11,14-tris(3-guanidinopropyl)-4,7,10,13,16,19,
Canonical SMILES CC([C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/C/N=C(O)/[C@](N)([H])CC1=CC=C(O)C=C1)([H])CC2=CC=CC=C2)([H])CCSC)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])/C(O)=N/C/C(O)=N/[C@@](C(N3CCC[C@@]3([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=
分子式 C130H184N38O31S2 分子量 2839.22
溶解度 Soluble to 1 mg/ml in Water 储存条件 Desiccate at -20°C
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1 mM 0.3522 mL 1.761 mL 3.5221 mL
5 mM 0.0704 mL 0.3522 mL 0.7044 mL
10 mM 0.0352 mL 0.1761 mL 0.3522 mL
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