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Altretamine Sale

(Synonyms: 六甲蜜胺; ENT-50852; RB-1515; WR-95704) 目录号 : GC14564

An antineoplastic agent and GPX4 inhibitor

Altretamine Chemical Structure

Cas No.:645-05-6

规格 价格 库存 购买数量
100mg
¥540.00
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Sample solution is provided at 25 µL, 10mM.

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实验参考方法

Animal experiment:

Mice[1]Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].

References:

[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

产品描述

Altretamine is an alkylating antineoplastic agent.

Altretamine is an antineoplastic agent[1].

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].

References:
[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

Chemical Properties

Cas No. 645-05-6 SDF
别名 六甲蜜胺; ENT-50852; RB-1515; WR-95704
化学名 2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine
Canonical SMILES CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C
分子式 C9H18N6 分子量 210.28
溶解度 ≥ 36.3 mg/mL in DMSO with ultrasonic, ≥ 8.85 mg/mL in Ethanol 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.7556 mL 23.7778 mL 47.5556 mL
5 mM 0.9511 mL 4.7556 mL 9.5111 mL
10 mM 0.4756 mL 2.3778 mL 4.7556 mL
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