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α-Hydroxylinoleic acid Sale

(Synonyms: α-羟基油酸; α-Hydroxylinoleic acid) 目录号 : GC30761

ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

α-Hydroxylinoleic acid Chemical Structure

Cas No.:57818-44-7

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Sample solution is provided at 25 µL, 10mM.

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产品描述

ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.

ABTL0812 inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. Furthermore, treatment with ABTL0812 also induces AMPK activation and ROS accumulation. Moreover, combination of ABTL0812 with chemotherapy markedly increases the therapeutic effect of chemotherapy without increasing toxicity. Combination of ABTL0812 and chemotherapy induces nonapoptotic cell death mediated by TRIB3 activation and autophagy induction.[1]

ABTL0812 enhances carboplatin and paclitaxel antitumor activity both in adenocarcinomas and squamous lung xenografts.[1]

[1] Anna López-Plana, et al. Int J Cancer. 2020 Aug 15;147(4):1163-1179.

Chemical Properties

Cas No. 57818-44-7 SDF
别名 α-羟基油酸; α-Hydroxylinoleic acid
Canonical SMILES CCCCC/C=C\C/C=C\CCCCCCC(O)C(O)=O
分子式 C18H32O3 分子量 296.44
溶解度 DMSO: 5 mg/mL (16.87 mM) 储存条件 Store at -20°C
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1 mM 3.3734 mL 16.8668 mL 33.7336 mL
5 mM 0.6747 mL 3.3734 mL 6.7467 mL
10 mM 0.3373 mL 1.6867 mL 3.3734 mL
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