Acetone-d6
(Synonyms: 氘代丙酮) 目录号 : GC63638
Acetone-d6 是 Acetone 的氘代物，可用作核磁共振波谱 (NMR) 的溶剂。
Cas No.:666-52-4
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acetone-d6, the deuterium labeled Acetone, is a deuterated nuclear magnetic resonance (NMR) solvent[1].
[1]. Kim HJ, et, al. Simple and automatic determination of aldehydes and acetone in water by headspace solid-phase microextraction and gas chromatography-mass spectrometry. J Sep Sci. 2011 Mar;34(6):693-9.
| Cas No. | 666-52-4 | SDF | |
| 别名 | 氘代丙酮 | ||
| 分子式 | C3D6O | 分子量 | 64.12 |
| 溶解度 | 储存条件 | 4°C, stored under argon | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 15.5958 mL | 77.9788 mL | 155.9576 mL |
| 5 mM | 3.1192 mL | 15.5958 mL | 31.1915 mL |
| 10 mM | 1.5596 mL | 7.7979 mL | 15.5958 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Achievement of 1020MHz NMR
J Magn Reson 2015 Jul;256:30-33.PMID:25978708DOI:10.1016/j.jmr.2015.04.009.
We have successfully developed a 1020MHz (24.0T) NMR magnet, establishing the world's highest magnetic field in high resolution NMR superconducting magnets. The magnet is a series connection of LTS (low-Tc superconductors NbTi and Nb3Sn) outer coils and an HTS (high-Tc superconductor, Bi-2223) innermost coil, being operated at superfluid liquid helium temperature such as around 1.8K and in a driven-mode by an external DC power supply. The drift of the magnetic field was initially ±0.8ppm/10h without the (2)H lock operation; it was then stabilized to be less than 1ppb/10h by using an NMR internal lock operation. The full-width at half maximum of a (1)H spectrum taken for 1% CHCl3 in Acetone-d6 was as low as 0.7Hz (0.7ppb), which was sufficient for solution NMR. On the contrary, the temporal field stability under the external lock operation for solid-state NMR was 170ppb/10h, sufficient for NMR measurements for quadrupolar nuclei such as (17)O; a (17)O NMR measurement for labeled tri-peptide clearly demonstrated the effect of high magnetic field on solid-state NMR spectra.
Multicomponent Self-Assembled Metal-Organic [3]Rotaxanes
J Am Chem Soc 2015 Oct 14;137(40):12966-76.PMID:26378806DOI:10.1021/jacs.5b07308.
A set of environmentally responsive metal-organic [3]rotaxanes is described. These mechanically interlocked macromolecules may be prepared in quantitative yield via a one-pot procedure involving treatment of a flexible tetracationic macrocycle, known as the Texas-sized molecular box, with tri-1,3,5-benzenetricarboxylate anion and silver cations (Ag(+)). The use of this three-component mixture gives rise to a metal-organic [3]rotaxane via a self-assembly process that occurs under ambient conditions in DMSO-d6 solution. The complex is stable in the presence of excess TFA. However, disassembly of the [3]rotaxane to produce anion-box associated entities may be triggered by adding a competitive counteranionic species (e.g., I(-)). Adding excess Ag(+) serves to reverse this decomplexation process. The nature of the [3]rotaxane complex could be fine-tuned via application of an external stimulus. Increasing the temperature or adding small molecules (e.g., D2O, methanol-d4, acetonitrile-d3, DMF-d7, Acetone-d6, or THF-d8) to the initial DMSO-d6 solution induces conformational flipping of the macrocycle within the overall complex (e.g., from limiting chair to chairlike forms). Support for the molecular stimuli responsive nature of the various structures came from solution-phase one- and two-dimensional ((1)H, 1D and 2D NOESY) NMR spectroscopic studies carried out in DMSO-d6. The core metal-linked rotaxane unit was characterized via single-crystal X-ray diffraction analysis. Initial evidence that the present self-assembly process is not limited to the use of the Ag(+) cation came from studies involving Cd(2+); this replacement results in formation of 2D metal-organic rotaxane-containing frameworks (MORFs).
Poly(sulfobetaine)-Based Diblock Copolymer Thin Films in Water/Acetone Atmosphere: Modulation of Water Hydration and Co-nonsolvency-Triggered Film Contraction
Langmuir 2022 Jun 7;38(22):6934-6948.PMID:35609178DOI:10.1021/acs.langmuir.2c00451.
The water swelling and subsequent solvent exchange including co-nonsolvency behavior of thin films of a doubly thermo-responsive diblock copolymer (DBC) are studied via spectral reflectance, time-of-flight neutron reflectometry, and Fourier transform infrared spectroscopy. The DBC consists of a thermo-responsive zwitterionic (poly(4-((3-methacrylamidopropyl) dimethylammonio) butane-1-sulfonate)) (PSBP) block, featuring an upper critical solution temperature transition in aqueous media but being insoluble in acetone, and a nonionic poly(N-isopropylmethacrylamide) (PNIPMAM) block, featuring a lower critical solution temperature transition in water, while being soluble in acetone. Homogeneous DBC films of 50-100 nm thickness are first swollen in saturated water vapor (H2O or D2O), before they are subjected to a contraction process by exposure to mixed saturated water/acetone vapor (H2O or D2O/Acetone-d6 = 9:1 v/v). The affinity of the DBC film toward H2O is stronger than for D2O, as inferred from the higher film thickness in the swollen state and the higher absorbed water content, thus revealing a pronounced isotope sensitivity. During the co-solvent-induced switching by mixed water/acetone vapor, a two-step film contraction is observed, which is attributed to the delayed expulsion of water molecules and uptake of acetone molecules. The swelling kinetics are compared for both mixed vapors (H2O/Acetone-d6 and D2O/Acetone-d6) and with those of the related homopolymer films. Moreover, the concomitant variations of the local environment around the hydrophilic groups located in the PSBP and PNIPMAM blocks are followed. The first contraction step turns out to be dominated by the behavior of the PSBP block, whereas the second one is dominated by the PNIPMAM block. The unusual swelling and contraction behavior of the latter block is attributed to its co-nonsolvency behavior. Furthermore, we observe cooperative hydration effects in the DBC films, that is, both polymer blocks influence each other's solvation behavior.
Acetone-h6 or -d6 + OH reaction products: evidence for heterogeneous formation of acetic acid in a simulation chamber
Environ Sci Technol 2006 Oct 1;40(19):5956-61.PMID:17051785DOI:10.1021/es060183a.
Simulation chamber experiments have been carried out at room temperature to investigate the products of the acetone + OH and Acetone-d6 + OH reactions using two photoreactors made of Teflon or Pyrex and coupled to GC-FTIR-FID analytical techniques. In the Pyrex chamber, the results demonstrated that the channel forming acetic acid is a minor oxidation route in the atmospheric acetone-h6 + OH reaction (yield <5%), whereas a higher yield of about 20% was obtained in the case of the Acetone-d6 + OH reaction, in good agreement with previous studies. Existence of a heterogeneous way of formation of acetic acid has also been identified in the Teflon photoreactor.
Singlet-oxygen generation from A2E
Photochem Photobiol 2003 Mar;77(3):235-42.PMID:12685649DOI:10.1562/0031-8655(2003)077<0235:sogfa>2.0.co;2.
Singlet-oxygen generation was measured in solutions containing equilibrium mixtures of the retinal lipofuscins, 2-[2, 6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)- 1E,3E,5E,7Eoctatetraenyl]-1-(2-hydroxyethyl)-4-[4-methyl-6(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E-hexatrienyl]-pyridinium (A2E) and double bond isomer of A2E (iso-A2E), using steady-state irradiation and using cholesterol as a singlet-oxygen trap. The amount of singlet oxygen generated by equilibrium mixtures of A2E and iso-A2E was compared with that generated by tetraphenylporphine (TPP) under the same conditions. Studies were carried out in ethanol-d6, Acetone-d6, 80% cyclohexane-d(12)-20% Acetone-d6 (vol/vol) and hexafluorobenzene. Using 420 nm irradiation and assuming a singlet-oxygen quantum yield of 0.60 +/- 0.12 for TPP, the singlet-oxygen quantum yields were 0.8 +/- 0.3 x 10(-3), 1.2 +/- 0.4 x 10(-3), 2 +/- 1 x 10(-3) and 4 + 1 x 10(-3), respectively. In Acetone-d6, the quantum yields were smaller at longer wavelengths, with values of 0.3 +/- 0.1 x 10(-3) and 0.4 +/- 0.2 x 10(-3) at 461 and 493 nm, respectively. Singlet-oxygen generation was greatest in solvents with the lowest dielectric constants. In view of the relatively small quantum yields, the contribution of singlet-oxygen generation to the phototoxic properties of A2E and of iso-A2E will require further study.