Home>>Signaling Pathways>> Neuroscience>> GABA Receptor>>(2S)-6-Prenylnaringenin

(2S)-6-Prenylnaringenin Sale

(Synonyms: (2S)-6-异戊烯基柚皮素) 目录号 : GC60000

A prenylated flavonoid with diverse biological activities

(2S)-6-Prenylnaringenin Chemical Structure

Cas No.:68236-13-5

规格 价格 库存 购买数量
1mg
¥1,368.00
现货
5mg
¥3,420.00
现货
10mg
¥5,400.00
现货

电话:400-920-5774 Email: sales@glpbio.cn

Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

View current batch:

产品描述

(2S)-6-Prenylnaringenin is a prenylated flavonoid that has been found in the hop plant, H. lupulus, and has diverse biological activities.1,2 It inhibits the T-type voltage-gated calcium (Cav) channel Cav3.2 in HEK293 cells and high-voltage-activated calcium currents in differentiated NG 108-15 cells in whole-cell patch-clamp assays (IC50s = 0.928 and 2.005 ?M, respectively).1 (2S)-6-Prenylnaringenin reduces the activity of aldose reductase 2 (ALR2; IC50 = 6.2 ?M for the recombinant human enzyme).2 It reduces mechanical allodynia in a mouse model of sodium hydrosulfide-induced somatic pain when administered at a dose of 10 pmol/paw.1

1.Sekiguchi, F., Fujita, T., Deguchi, T., et al.Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in miceNeuropharmacology138232-244(2018) 2.Shim, S.H., Kim, Y., Lee, J.Y., et al.Aldose reductase inhibitory activity of the compounds from the seed of Psoralea corylifoliaJ. Korean Soc. Appl. Biol. Chem.52(5)568–572(2009)

Chemical Properties

Cas No. 68236-13-5 SDF
别名 (2S)-6-异戊烯基柚皮素
Canonical SMILES OC1=C2C(O[C@H](C3=CC=C(O)C=C3)CC2=O)=CC(O)=C1C/C=C(C)/C
分子式 C20H20O5 分子量 340.37
溶解度 储存条件
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

制备储备液
1 mg 5 mg 10 mg
1 mM 2.938 mL 14.6899 mL 29.3798 mL
5 mM 0.5876 mL 2.938 mL 5.876 mL
10 mM 0.2938 mL 1.469 mL 2.938 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

质量
=
浓度
x
体积
x
分子量
 
 
 
*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。

计算

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % saline
计算重置

Research Update

Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice

Neuropharmacology 2018 Aug;138:232-244.PMID:29913186DOI:10.1016/j.neuropharm.2018.06.020

Since Cav3.2 T-type Ca2+ channels (T-channels) expressed in the primary afferents and CNS contribute to intractable pain, we explored T-channel-blocking components in distinct herbal extracts using a whole-cell patch-clamp technique in HEK293 cells stably expressing Cav3.2 or Cav3.1, and purified and identified sophoraflavanone G (SG) as an active compound from SOPHORAE RADIX (SR). Interestingly, hop-derived SG analogues, (2S)-6-Prenylnaringenin (6-PNG) and (2S)-8-PNG, but not naringenin, also blocked T-channels; IC50 (μM) of SG, (2S)-6-PNG and (2S)-8-PNG was 0.68-0.75 for Cav3.2 and 0.99-1.41 for Cav3.1. (2S)-6-PNG and (2S)-8-PNG, but not SG, exhibited reversible inhibition. The racemic (2R/S)-6-PNG as well as (2S)-6-PNG potently blocked Cav3.2, but exhibited minor effect on high-voltage-activated Ca2+ channels and voltage-gated Na+ channels in differentiated NG108-15 cells. In mice, the mechanical allodynia following intraplantar (i.pl.) administration of an H2S donor was abolished by oral or i.p. SR extract and by i.pl. SG, (2S)-6-PNG or (2S)-8-PNG, but not naringenin. Intraperitoneal (2R/S)-6-PNG strongly suppressed visceral pain and spinal ERK phosphorylation following intracolonic administration of an H2S donor in mice. (2R/S)-6-PNG, administered i.pl. or i.p., suppressed the neuropathic allodynia induced by partial sciatic nerve ligation or oxaliplatin, an anti-cancer agent, in mice. (2R/S)-6-PNG had little or no effect on open-field behavior, motor performance or cardiovascular function in mice, and on the contractility of isolated rat aorta. (2R/S)-6-PNG, but not SG, was detectable in the brain after their i.p. administration in mice. Our data suggest that 6-PNG, a hop component, blocks T-channels, and alleviates neuropathic and visceral pain with little side effects.