Home>>13,14-dihydro-16,16-difluoro Prostaglandin D2

13,14-dihydro-16,16-difluoro Prostaglandin D2 Sale

目录号 : GC46430

A neuropeptide with diverse biological activities

13,14-dihydro-16,16-difluoro Prostaglandin D2 Chemical Structure

规格 价格 库存 购买数量
100 μg
¥531.00
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500 μg
¥2,399.00
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1 mg
¥4,249.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Prostaglandin D2 (PGD2) plays important roles in vascular smooth muscle relaxation, the inhibition of platelet aggregation, and anaphylaxis. 13,14-dihydro-16,16-difluoro PGD2 is an analog of PGD2. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo.1 Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGD2 could be biologically active.2,3

1.Hatano, Y., Kohli, J.D., Goldberg, L.I., et al.Vascular relaxing activity and stability studies of 10,10-difluoro-13,14-dehydroprostacyclinProceedings of the National Academy of Sciences of the United States of America77(11)6846-6850(1980) 2.ÄnggÅrd, E.The biological activities of three metabolites of prostaglandin E1Acta Physiologica Scandinavica66509-510(1966) 3.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971)

Chemical Properties

Cas No. N/A SDF
Canonical SMILES O=C1[C@H](CC[C@@H](O)C(F)(F)CCCC)[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1
分子式 C20H32F2O5 分子量 390.5
溶解度 DMF: 14 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 15 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.5608 mL 12.8041 mL 25.6082 mL
5 mM 0.5122 mL 2.5608 mL 5.1216 mL
10 mM 0.2561 mL 1.2804 mL 2.5608 mL
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