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1H-1-ethyl Candesartan Cilexetil Sale

(Synonyms: 坎地沙坦EP杂质E) 目录号 : GC17757

A potential impurity found in bulk preparations of candesartan cilexetil

1H-1-ethyl Candesartan Cilexetil Chemical Structure

Cas No.:914613-35-7

规格 价格 库存 购买数量
1mg
¥793.00
现货
5mg
¥3,093.00
现货
10mg
¥4,647.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.

Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

References:
[1].  Otsuka, M. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004; 59(1): 31-38.
[2].  GUO, D., SUN, Y., HAMET, P., & INAGAMI, T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Research. 2001; 11(3): 165-180.

Chemical Properties

Cas No. 914613-35-7 SDF
别名 坎地沙坦EP杂质E
化学名 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Canonical SMILES O=C(OC(C)OC(C1=C(N(CC2=CC=C(C3=C(C4=NN=NN4CC)C=CC=C3)C=C2)C(OCC)=N5)C5=CC=C1)=O)OC6CCCCC6
分子式 C35H38N6O6 分子量 638.7
溶解度 ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.5657 mL 7.8284 mL 15.6568 mL
5 mM 0.3131 mL 1.5657 mL 3.1314 mL
10 mM 0.1566 mL 0.7828 mL 1.5657 mL
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